{"product_id":"trim23-antibody-tripartite-motif-containing-protein-23-bha17136038","title":"TRIM23 Antibody \/ Tripartite motif-containing protein 23","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTRIM23 Antibody \/ Tripartite motif-containing protein 23 is a anti-TRIM23 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRIM23\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTRIM23 antibody detects Tripartite motif-containing protein 23, a multifunctional E3 ubiquitin ligase involved in autophagy, vesicle trafficking, and innate immunity. The UniProt recommended name is Tripartite motif-containing protein 23 (TRIM23). This cytoplasmic protein belongs to the TRIM family, characterized by RING, B-box, and coiled-coil domains mediating protein-protein interactions and ubiquitin ligase activity.\u003cbr\u003e\u003cbr\u003eFunctionally, TRIM23 antibody identifies a 586-amino-acid protein that regulates signaling complexes and autophagy. TRIM23 ubiquitinates and activates TBK1 kinase, promoting antiviral autophagy and interferon responses. It also coordinates endomembrane trafficking by acting as an Arf GAP (GTPase-activating protein), linking vesicular dynamics to immune signaling.\u003cbr\u003e\u003cbr\u003eThe TRIM23 gene is located on chromosome 5q12.3 and is expressed in multiple tissues, with highest levels in brain, lung, and immune cells. Through its dual ubiquitin ligase and Arf GAP activities, TRIM23 integrates membrane trafficking and host defense. It contributes to selective autophagy of pathogens and protein aggregates.\u003cbr\u003e\u003cbr\u003ePathologically, altered TRIM23 expression has been associated with neurodegeneration, viral infection, and cancer. In neurons, TRIM23 maintains axonal homeostasis, while in immune cells it regulates autophagic responses. Research using TRIM23 antibody supports studies in innate immunity, autophagy, and vesicle biology.\u003cbr\u003e\u003cbr\u003eTRIM23 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect E3 ligases and autophagy regulators. \u003cbr\u003e\u003cbr\u003eStructurally, Tripartite motif-containing protein 23 features a RING finger domain for E3 ligase activity, B-box and coiled-coil domains for dimerization, and a C-terminal ARF GAP domain. This antibody supports detailed analysis of TRIM23's regulatory roles in autophagy and innate immune signaling.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TRIM23 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TRIM23 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TRIM23 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TRIM23 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TRIM23+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047312974189,"sku":"FY13136","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_62a01c16-f12e-4146-9b40-3fa83048b0ba.jpg?v=1782237089","url":"https:\/\/www.ebiohippo.com\/products\/trim23-antibody-tripartite-motif-containing-protein-23-bha17136038","provider":"BioHippo","version":"1.0","type":"link"}