{"product_id":"trim47-antibody-tripartite-motif-containing-protein-47-bha17135913","title":"TRIM47 Antibody \/ Tripartite motif-containing protein 47","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTRIM47 Antibody \/ Tripartite motif-containing protein 47 is a anti-TRIM47 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRIM47\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC\/IF, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTRIM47 antibody detects Tripartite motif-containing protein 47, an E3 ubiquitin ligase that regulates protein degradation, signal transduction, and immune responses. The UniProt recommended name is Tripartite motif-containing protein 47 (TRIM47). This protein is a member of the TRIM family characterized by the RING finger, B-box, and coiled-coil domains that define its ubiquitin ligase function and protein interaction capacity.\u003cbr\u003e\u003cbr\u003eFunctionally, TRIM47 antibody identifies a 638-amino-acid cytoplasmic and nuclear protein that facilitates ubiquitination of target substrates, marking them for proteasomal degradation or functional modification. TRIM47 modulates diverse cellular pathways, including interferon signaling, MAPK activation, and cell cycle regulation. Its ligase activity controls turnover of key signaling mediators, contributing to immune homeostasis and stress response.\u003cbr\u003e\u003cbr\u003eThe TRIM47 gene is located on chromosome 17q24.3 and is expressed in multiple tissues, including brain, kidney, and endothelial cells. TRIM47 interacts with adaptor proteins and kinases to regulate NF-kappaB activation, antiviral defense, and inflammatory signaling. It has also been implicated in the regulation of apoptosis and autophagy, linking ubiquitin signaling to cellular stress adaptation. TRIM47 may influence the degradation of misfolded or damaged proteins during oxidative or inflammatory stress.\u003cbr\u003e\u003cbr\u003eIn cancer biology, TRIM47 acts as an oncogenic factor in glioma, lung adenocarcinoma, and prostate cancer, where it promotes proliferation and metastasis by modulating MAPK and STAT3 pathways. Overexpression correlates with poor prognosis and enhanced resistance to apoptosis. Conversely, loss of TRIM47 activity may impair innate immune signaling, reducing antiviral defenses and inflammatory gene activation.\u003cbr\u003e\u003cbr\u003eTRIM47 antibody is widely used in studies of ubiquitin signaling, innate immunity, and cancer biology. It is suitable for western blotting, immunoprecipitation, and immunofluorescence to examine TRIM47 expression and interactions. In immunology, this antibody supports investigations of antiviral pathways and cytokine regulation. In oncology, TRIM47 serves as a potential biomarker of tumor aggressiveness and therapeutic resistance.\u003cbr\u003e\u003cbr\u003eStructurally, TRIM47 contains a RING-type zinc-binding motif conferring E3 ligase activity, B-box domains for stability, and a coiled-coil region for multimerization. Its C-terminal PRY\/SPRY domain mediates substrate recognition and specificity.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TRIM47 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TRIM47 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TRIM47 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TRIM47 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TRIM47+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047309074797,"sku":"FY13011","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7d311e59-b15f-4218-843c-8e46ad3e1237.jpg?v=1782237082","url":"https:\/\/www.ebiohippo.com\/products\/trim47-antibody-tripartite-motif-containing-protein-47-bha17135913","provider":"BioHippo","version":"1.0","type":"link"}