{"product_id":"trip11-antibody-thyroid-receptor-interacting-protein-11-gmap-210-bha17135678","title":"TRIP11 Antibody \/ Thyroid receptor-interacting protein 11 \/ GMAP-210","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTRIP11 Antibody \/ Thyroid receptor-interacting protein 11 \/ GMAP-210 is a anti-TRIP11 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TRIP11\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTRIP11 antibody detects Thyroid receptor-interacting protein 11 (also known as GMAP-210), a large coiled-coil Golgi microtubule-associated protein involved in maintaining Golgi structure and vesicle trafficking. Encoded by the TRIP11 gene on chromosome 14q32.12, this protein functions as a tethering factor that anchors vesicles to the Golgi membrane, facilitating directional transport between the endoplasmic reticulum (ER) and Golgi apparatus. GMAP-210 is essential for Golgi organization, ciliary assembly, and protein glycosylation, linking cytoskeletal dynamics to secretory pathway regulation.\u003cbr\u003e\u003cbr\u003eTRIP11\/GMAP-210 contains an N-terminal GRAB domain that interacts with the small GTPase ARF1 and a C-terminal acidic motif that binds to vesicular membranes. These dual binding regions enable the protein to bridge vesicles and the Golgi surface, stabilizing Golgi ribbon structure and promoting vesicle docking. In addition, its extended coiled-coil conformation provides a physical scaffold that organizes Golgi cisternae and positions them relative to the microtubule network. Depletion or mutation of GMAP-210 results in Golgi fragmentation, defective cargo trafficking, and impaired ciliary protein transport.\u003cbr\u003e\u003cbr\u003eThe TRIP11 antibody is widely used in cell biology, neurobiology, and developmental research to study Golgi morphology and vesicle tethering. Western blot analysis typically identifies a 210 kilodalton band corresponding to full-length GMAP-210, while immunofluorescence reveals Golgi-localized perinuclear staining. This antibody enables detailed visualization of Golgi organization, vesicle docking, and intracellular transport pathways.\u003cbr\u003e\u003cbr\u003eMutations in TRIP11 cause achondrogenesis type 1A, a lethal skeletal dysplasia resulting from defective protein secretion and ciliary dysfunction. Beyond skeletal disease, altered expression of GMAP-210 affects neural development, epithelial polarization, and secretion of extracellular matrix proteins. The TRIP11 antibody supports research into Golgi-associated transport, ciliogenesis, and protein trafficking disorders.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TRIP11 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TRIP11 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TRIP11 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TRIP11 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TRIP11+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047299768685,"sku":"FY12775","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_276af4fc-86f0-4a41-9703-7f9447b45471.jpg?v=1782237043","url":"https:\/\/www.ebiohippo.com\/products\/trip11-antibody-thyroid-receptor-interacting-protein-11-gmap-210-bha17135678","provider":"BioHippo","version":"1.0","type":"link"}