{"product_id":"ttbk1-antibody-tau-tubulin-kinase-1-bha17136158","title":"TTBK1 Antibody \/ Tau-tubulin kinase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTTBK1 Antibody \/ Tau-tubulin kinase 1 is a anti-TTBK1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TTBK1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTTBK1 antibody detects Tau-tubulin kinase 1, a serine\/threonine kinase involved in microtubule regulation, neuronal polarization, and tau protein phosphorylation. The UniProt recommended name is Tau-tubulin kinase 1 (TTBK1). This neuron-specific kinase phosphorylates tau and tubulin to modulate microtubule dynamics and axonal stability, playing key roles in neurodevelopment and neurodegenerative disease.\u003cbr\u003e\u003cbr\u003eFunctionally, TTBK1 antibody identifies a 1,326-amino-acid cytoplasmic and axonal kinase that phosphorylates tau at multiple sites, including those associated with Alzheimer's disease pathology. TTBK1 regulates microtubule nucleation and cilia disassembly, contributing to neuronal morphogenesis and signaling. It is primarily expressed in the cerebral cortex, hippocampus, and cerebellum, where it modulates cytoskeletal organization and synaptic plasticity.\u003cbr\u003e\u003cbr\u003eThe TTBK1 gene is located on chromosome 6p21.1 and is expressed predominantly in neurons. Expression is upregulated during axonal outgrowth and differentiation, linking kinase activity to neural development. TTBK1 functions within signaling cascades involving CDK5 and GSK3beta, coordinating tau modification and cytoskeletal remodeling in neurons.\u003cbr\u003e\u003cbr\u003ePathologically, aberrant activation or overexpression of TTBK1 contributes to tau hyperphosphorylation, neurofibrillary tangle formation, and neuronal death in Alzheimer's disease and other tauopathies. Mutations or altered regulation may also affect primary cilia dynamics and neuronal polarity. Research using TTBK1 antibody supports studies in neurodegeneration, kinase signaling, and cytoskeletal biology.\u003cbr\u003e\u003cbr\u003eTTBK1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect neuronal kinases. \u003cbr\u003e\u003cbr\u003eStructurally, Tau-tubulin kinase 1 contains an N-terminal kinase domain with conserved ATP-binding and catalytic residues, and a C-terminal regulatory region that mediates substrate specificity and microtubule association. TTBK1 undergoes autophosphorylation and dynamic localization between cytoplasm and axon terminals. This antibody enables detailed examination of TTBK1's role in neuronal architecture and tau-related pathology.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TTBK1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TTBK1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TTBK1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TTBK1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TTBK1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047320772973,"sku":"FY13256","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fbdba850-b134-416b-b328-02a180760998.jpg?v=1782237087","url":"https:\/\/www.ebiohippo.com\/products\/ttbk1-antibody-tau-tubulin-kinase-1-bha17136158","provider":"BioHippo","version":"1.0","type":"link"}