{"product_id":"ttc36-antibody-tetratricopeptide-repeat-protein-36-bha17135993","title":"TTC36 Antibody \/ Tetratricopeptide repeat protein 36","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTTC36 Antibody \/ Tetratricopeptide repeat protein 36 is a anti-TTC36 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TTC36\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTTC36 antibody detects Tetratricopeptide repeat protein 36, a cytoplasmic protein containing multiple TPR motifs that mediate protein-protein interactions involved in cellular signaling and structural organization. The UniProt recommended name is Tetratricopeptide repeat protein 36 (TTC36). Although not fully characterized, TTC36 is believed to function as a molecular scaffold, facilitating the assembly of multiprotein complexes that regulate cell differentiation and signal transduction.\u003cbr\u003e\u003cbr\u003eFunctionally, TTC36 antibody identifies a 356-amino-acid protein rich in tetratricopeptide repeat sequences, which serve as recognition modules for chaperones and signaling enzymes. TTC36 interacts with cytoskeletal and membrane-associated proteins, suggesting roles in maintaining cell integrity and coordinating intracellular signaling. Its TPR domains likely promote conformational flexibility, enabling diverse binding partners.\u003cbr\u003e\u003cbr\u003eThe TTC36 gene is located on chromosome 6q22.33 and is expressed in epithelial tissues, gastrointestinal tract, and reproductive organs. Gene expression analyses indicate regulation by Wnt and TGF-beta pathways, implicating TTC36 in developmental and oncogenic signaling. Its expression in enterocytes and hepatocytes supports potential functions in nutrient transport or cellular adhesion.\u003cbr\u003e\u003cbr\u003ePathologically, altered TTC36 expression has been reported in several cancers, including hepatocellular carcinoma and gastric cancer, where its downregulation correlates with increased tumor growth and metastasis. TTC36 is thought to act as a tumor suppressor by modulating signaling cascades that control cell proliferation and adhesion. Research with TTC36 antibody aids in exploring these molecular interactions and their impact on cancer progression.\u003cbr\u003e\u003cbr\u003eTTC36 antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence to detect cytoplasmic TPR-containing scaffolds. \u003cbr\u003e\u003cbr\u003eStructurally, TTC36 features tandem TPR motifs that create a solenoid-like architecture, enabling multipoint interactions with diverse proteins. This antibody supports detailed investigations into TTC36's scaffolding roles in intracellular communication and cancer biology.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TTC36 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TTC36 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TTC36 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TTC36 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TTC36+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047312941421,"sku":"FY13091","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5d2edbc9-4aa9-4a32-96e9-e043982f69b1.jpg?v=1782237104","url":"https:\/\/www.ebiohippo.com\/products\/ttc36-antibody-tetratricopeptide-repeat-protein-36-bha17135993","provider":"BioHippo","version":"1.0","type":"link"}