{"product_id":"tunel-apoptosis-detection-kit-ysfluortm-488-bht20800107","title":"TUNEL Apoptosis Detection Kit (YSFluorTM 488)","description":"\u003cdiv class=\"product-block-list__item product-block-list__item--description\"\u003e\n                    \u003cdiv class=\"card\"\u003e\n\u003cdiv class=\"card__header\"\u003e\n                          \u003ch2 class=\"card__title heading h3\"\u003eDescription\u003c\/h2\u003e\n                        \u003c\/div\u003e\n\n                        \u003cdiv class=\"card__section \"\u003e\n                          \u003cdiv class=\"rte text--pull\"\u003e\n                            \u003cdiv class=\"top_tabc proDetail\" data-v-444b0c7e=\"\"\u003e\n\u003cdiv data-v-444b0c7e=\"\"\u003e\n\u003cdiv data-v-444b0c7e=\"\"\u003e\n\u003cp align=\"justify\"\u003eDuring apoptosis, cells activate certain DNA endonucleases that cleave genomic DNA between nucleosomes. When DNA is extracted from apoptotic cells and analyzed by electrophoresis, a characteristic DNA ladder of ~180–200 bp fragments can be observed.\u003c\/p\u003e\n\u003cp align=\"justify\"\u003eThe TUNEL (TdT-mediated dUTP Nick-End Labeling) Apoptosis Detection Kit (YSFluor™ 488) is designed to detect DNA fragmentation in the nuclei of cells during late-stage apoptosis. The principle is based on the enzymatic activity of Terminal Deoxynucleotidyl Transferase (TdT), which catalyzes the incorporation of YSFluor™ 488-12-dUTP into the 3′-hydroxyl (3′-OH) ends of fragmented DNA. The labeled DNA can then be visualized using a fluorescence microscope or analyzed by flow cytometry.\u003c\/p\u003e\n\u003cp align=\"justify\"\u003eYSFluor™ 488 offers higher photostability and stronger fluorescence intensity compared to conventional dyes, resulting in brighter labeling and enhanced resistance to photobleaching.\u003c\/p\u003e\n\u003cp align=\"justify\"\u003eThis kit is broadly applicable and can be used to detect apoptosis in:\u003c\/p\u003e\n\u003cp align=\"justify\"\u003eFormalin-fixed paraffin-embedded (FFPE) tissue sections; Frozen tissue sections; Cultured adherent or suspension cells.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eFeatures\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli align=\"justify\"\u003eBroad applicability: Suitable for apoptosis detection in frozen or paraffin-embedded tissue sections, as well as in adherent and suspension cell cultures.\u003c\/li\u003e\n\u003cli align=\"justify\"\u003eHigh sensitivity and specificity: Accurately distinguishes apoptotic cells from necrotic or normal cells through fluorescent labeling of DNA breaks.\u003c\/li\u003e\n\u003cli align=\"justify\"\u003eBright and stable fluorescence: YSFluor™ 488 provides strong green fluorescence with excellent photostability, ensuring clear and reproducible imaging.\u003c\/li\u003e\n\u003cli align=\"justify\"\u003eSimple and rapid protocol: Streamlined workflow for convenient use in various experimental setups.\u003c\/li\u003e\n\u003cli align=\"justify\"\u003eCompatible with multiple detection platforms: Applicable to fluorescence microscopy, flow cytometry, and high-content imaging systems.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eComponents\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ctable cellspacing=\"0\" border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"180\"\u003e\n\u003cp\u003eComponents No.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"341\"\u003e\n\u003cp\u003eName\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"154\"\u003e\n\u003cp\u003e40307ES20\u003c\/p\u003e\n\u003cp\u003e(20 T)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"154\"\u003e\n\u003cp\u003e40307ES50\u003c\/p\u003e\n\u003cp\u003e(50 T)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"154\"\u003e\n\u003cp\u003e40307ES60\u003c\/p\u003e\n\u003cp\u003e(100 T)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"center\" width=\"180\"\u003e\n\u003cp\u003e40307-A\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"341\"\u003e\n\u003cp\u003e5× Equilibration Buffer\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e750 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e1.25 mL × 2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e1.25 mL × 3\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"center\" width=\"180\"\u003e\n\u003cp\u003e40307-B\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"341\"\u003e\n\u003cp\u003eYSFluor™ 488-12-dUTP Labeling Mix\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e100 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e250 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e250 μL × 2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"center\" width=\"180\"\u003e\n\u003cp\u003e40307-C\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"341\"\u003e\n\u003cp\u003eRecombinant TdT Enzyme\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e20 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e50 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e50 μL × 2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"center\" width=\"180\"\u003e\n\u003cp\u003e40307-D\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"341\"\u003e\n\u003cp\u003eProteinase K (2 mg\/mL)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e40 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e100 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e100 μL × 2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"center\" width=\"180\"\u003e\n\u003cp\u003e40307-E\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"341\"\u003e\n\u003cp\u003eDNase I (1 U\/μL)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e5 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e12.5 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e25 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"center\" width=\"180\"\u003e\n\u003cp\u003e40307-F\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"341\"\u003e\n\u003cp\u003e10× DNase I Buffer with MgCl₂\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e100 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e250 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e500 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003e\u003cstrong\u003eStorage\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eShipped on wet ice.\u003c\/p\u003e\n\u003cp\u003eStore the entire kit at –25~-15°C. The YSFluor™ 488-12-dUTP Labeling Mix must be protected from light and stored at –20°C. The kit is stable for 1 year under these conditions.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eNotes\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003c!-- [if !supportLists]--\u003e1. \u003c!--[endif]--\u003eUsers must prepare the following reagents:\u003c\/p\u003e\n\u003cp\u003ePBS for cell washing\u003c\/p\u003e\n\u003cp\u003eAntifade mounting medium for microscopy\u003c\/p\u003e\n\u003cp\u003e4% paraformaldehyde (in PBS) for fixation\u003c\/p\u003e\n\u003cp\u003e\u003c!-- [if !supportLists]--\u003e2. \u003c!--[endif]--\u003eFor safety and hygiene, wear a lab coat and disposable gloves during handling.\u003c\/p\u003e\n\u003cp\u003e\u003c!-- [if !supportLists]--\u003e3. \u003c!--[endif]--\u003eThis product is for research use only!\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eDocuments:\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003eSafety Data Sheet\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40307-A-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20488)-MSDS-HB220805.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\u003cimg alt=\"\" data-v-98c835fc=\"\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40307-A-TUNEL Apoptosis Detection Kit (Alexa Fluor 488)-MSDS-HB220805.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40307-B-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20488)-MSDS-HB220805.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\u003cimg alt=\"\" data-v-98c835fc=\"\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40307-B-TUNEL Apoptosis Detection Kit (Alexa Fluor 488)-MSDS-HB220805.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40307-C-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20488)-MSDS-HB220805.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\u003cimg alt=\"\" data-v-98c835fc=\"\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40307-C-TUNEL Apoptosis Detection Kit (Alexa Fluor 488)-MSDS-HB220805.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40307-D-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20488)-MSDS-HB220805.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\u003cimg alt=\"\" data-v-98c835fc=\"\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40307-D-TUNEL Apoptosis Detection Kit (Alexa Fluor 488)-MSDS-HB220805.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40307-E-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20488)-MSDS-HB220805.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\u003cimg alt=\"\" data-v-98c835fc=\"\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40307-E-TUNEL Apoptosis Detection Kit (Alexa Fluor 488)-MSDS-HB220805.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40307-F-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20488)-MSDS-HB220805.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\u003cimg alt=\"\" data-v-98c835fc=\"\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40307-F-TUNEL Apoptosis Detection Kit (Alexa Fluor 488)-MSDS-HB220805.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003eManuals\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\n\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40307-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20488)-HB220805.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\u003cimg alt=\"\" data-v-98c835fc=\"\"\u003e\u003c\/a\u003e\n\u003cp data-v-98c835fc=\"\"\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0803\/9419\/1166\/files\/40307ES-Manual-Ver.EN20251111.pdf?v=1762926419\" title=\"download\" rel=\"noopener\" target=\"_blank\"\u003e40307-Manual-Ver.EN20251111.pdf\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch3\u003e\u003cstrong\u003ePublications Using This Product\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e[1] Tang Y, Fang G, Guo F, et al. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell. 2020;38(1):115-128.e9. doi:10.1016\/j.ccell.2020.05.019(IF:26.602)\u003c\/p\u003e\n\u003cp\u003e[2] Li Z, Zhang X, Xie S, et al. H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis [published online ahead of print, 2022 Jun 23]. Nucleic Acids Res. 2022;50(12):6786-6800. doi:10.1093\/nar\/gkac533(IF:16.971)\u003c\/p\u003e\n\u003cp\u003e[3] Jin X, Wang K, Wang L, et al. RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging. Autophagy. 2022;18(3):643-660. doi:10.1080\/15548627.2021.1946739(IF:16.016)\u003c\/p\u003e\n\u003cp\u003e[4] Chen Y, Wang Y, Chen J, et al. The SUN1-SPDYA interaction plays an essential role in meiosis prophase I. Nat Commun. 2021;12(1):3176. Published 2021 May 26. doi:10.1038\/s41467-021-23550-w(IF:14.919)\u003c\/p\u003e\n\u003cp\u003e[5] Liang W, Peng X, Li Q, et al. FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis. Nat Commun. 2020;11(1):5912. Published 2020 Nov 20. doi:10.1038\/s41467-020-19691-z(IF:12.121)\u003c\/p\u003e\n\u003cp\u003e[6] Zhang YJ, Zhang M, Zhao X, et al. NAD+ administration decreases microvascular damage following cardiac ischemia\/reperfusion by restoring autophagic flux. Basic Res Cardiol. 2020;115(5):57. Published 2020 Aug 10. doi:10.1007\/s00395-020-0817-z(IF:11.981)\u003c\/p\u003e\n\u003cp\u003e[7] Wang Y, Chen Y, Chen J, et al. The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope. Nat Commun. 2019;10(1):564. Published 2019 Feb 4. doi:10.1038\/s41467-019-08437-1(IF:11.878)\u003c\/p\u003e\n\u003cp\u003e[8] Yang B, Li L, Tong G, et al. Circular RNA circ_001422 promotes the progression and metastasis of osteosarcoma via the miR-195-5p\/FGF2\/PI3K\/Akt axis. J Exp Clin Cancer Res. 2021;40(1):235. Published 2021 Jul 16. doi:10.1186\/s13046-021-02027-0(IF:11.161)\u003c\/p\u003e\n\u003cp\u003e[9] Zhang M, Weng Y, Cao Z, et al. ROS-Activatable siRNA-Engineered Polyplex for NIR-Triggered Synergistic Cancer Treatment. ACS Appl Mater Interfaces. 2020;12(29):32289-32300. doi:10.1021\/acsami.0c06614(IF:8.758)\u003c\/p\u003e\n\u003cp\u003e[10] Zhou K, Zheng Z, Li Y, et al. TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress. Theranostics. 2020;10(20):9280-9302. Published 2020 Jul 23. doi:10.7150\/thno.46566(IF:8.579)\u003c\/p\u003e\n\u003cp\u003e[11] Yu H, Yang W, Huang J, et al. GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure. Cell Death Dis. 2021;13(1):1. Published 2021 Dec 16. doi:10.1038\/s41419-021-04394-0(IF:8.469)\u003c\/p\u003e\n\u003cp\u003e[12] Zhang H, Hao LZ, Pan JA, et al. Microfluidic fabrication of inhalable large porous microspheres loaded with H2S-releasing aspirin derivative for pulmonary arterial hypertension therapy. J Control Release. 2021;329:286-298. doi:10.1016\/j.jconrel.2020.11.060(IF:7.727)\u003c\/p\u003e\n\u003cp\u003e[13] Mao G, Xin D, Wang Q, Lai D. Sodium molybdate inhibits the growth of ovarian cancer cells via inducing both ferroptosis and apoptosis. Free Radic Biol Med. 2022;182:79-92. doi:10.1016\/j.freeradbiomed.2022.02.023(IF:7.376)\u003c\/p\u003e\n\u003cp\u003e[14] Xu T, Ding W, Ao X, et al. ARC regulates programmed necrosis and myocardial ischemia\/reperfusion injury through the inhibition of mPTP opening. Redox Biol. 2019;20:414-426. doi:10.1016\/j.redox.2018.10.023(IF:7.126)\u003c\/p\u003e\n\u003cp\u003e[15] Mao Y, Du J, Chen X, et al. Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2\/PINK1\/Parkin Pathway after Spinal Cord Injury. Oxid Med Cell Longev. 2022;2022:1337630. Published 2022 Feb 1. doi:10.1155\/2022\/1337630(IF:6.543)\u003c\/p\u003e\n\u003cp\u003e [16] Song S, Hou X, Zhang W, et al. Specific bFGF targeting of KIM-1 in ischemic kidneys protects against renal ischemia-reperfusion injury in rats. Regen Biomater. 2022;9:rbac029. Published 2022 May 12. doi:10.1093\/rb\/rbac029(IF:6.353)\u003c\/p\u003e\n\u003cp\u003e[17] Li Y, Zhang J, Zhou K, et al. Elevating sestrin2 attenuates endoplasmic reticulum stress and improves functional recovery through autophagy activation after spinal cord injury. Cell Biol Toxicol. 2021;37(3):401-419. doi:10.1007\/s10565-020-09550-4(IF:6.284)\u003c\/p\u003e\n\u003cp\u003e[18] Wu X, Zhang T, Lyu P, et al. Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ. Front Cardiovasc Med. 2021;8:698056. Published 2021 Jul 16. doi:10.3389\/fcvm.2021.698056(IF:6.050)\u003c\/p\u003e\n\u003cp\u003e[19] Pan JA, Tang Y, Yu JY, et al. miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b\/P53 pathway in doxorubicin-induced cardiotoxicity. Cell Death Dis. 2019;10(9):668. Published 2019 Sep 11. doi:10.1038\/s41419-019-1901-x(IF:5.959)\u003c\/p\u003e\n\u003cp\u003e[20] Zhang Y, He Z, Li Y, et al. Tumor cell membrane-derived nano-Trojan horses encapsulating phototherapy and chemotherapy are accepted by homologous tumor cells. Mater Sci Eng C Mater Biol Appl. 2021;120:111670. doi:10.1016\/j.msec.2020.111670(IF:5.880)\u003c\/p\u003e\n\u003cp\u003e[21] Kang H, Dong Y, Peng R, et al. Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo. Biochem Pharmacol. 2022;197:114932. doi:10.1016\/j.bcp.2022.114932(IF:5.858)\u003c\/p\u003e\n\u003cp\u003e[22] Jin J, Ma Y, Tong X, et al. Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK [published correction appears in Hum Reprod. 2020 Aug 1;35(8):1947-1948]. Hum Reprod. 2020;35(5):1145-1158. doi:10.1093\/humrep\/deaa077(IF:5.733)\u003c\/p\u003e\n\u003cp\u003e[23] Huang CX, Jiang ZX, Du DY, Zhang ZM, Liu Y, Li YT. The MFF-SIRT1\/3 axis, regulated by miR-340-5p, restores mitochondrial homeostasis of hypoxia-induced pulmonary artery smooth muscle cells. Lab Invest. 2022;102(5):515-523. doi:10.1038\/s41374-022-00730-w(IF:5.662)\u003c\/p\u003e\n\u003cp\u003e[24] Zhang S, Xing M, Chen G, Tong L, Zhang H, Du D. Up-regulation of miR-335 and miR-674-3p in the rostral ventrolateral medulla contributes to stress-induced hypertension. J Neurochem. 2022;161(5):387-404. doi:10.1111\/jnc.15589(IF:5.372)\u003c\/p\u003e\n\u003cp\u003e [25] Chen S, Sun Y, Li F, et al. 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