{"product_id":"tunel-apoptosis-detection-kit-ysfluortm-640-bht20800108","title":"TUNEL Apoptosis Detection Kit (YSFluorTM 640)","description":"\u003cdiv class=\"product-block-list__item product-block-list__item--description\"\u003e\n                    \u003cdiv class=\"card\"\u003e\n\u003cdiv class=\"card__header\"\u003e\n                          \u003ch2 class=\"card__title heading h3\"\u003eDescription\u003c\/h2\u003e\n                        \u003c\/div\u003e\n\n                        \u003cdiv class=\"card__section \"\u003e\n                          \u003cdiv class=\"rte text--pull\"\u003e\n                            \u003cdiv class=\"top_tabc proDetail\" data-v-444b0c7e=\"\"\u003e\n\u003cdiv data-v-444b0c7e=\"\"\u003e\n\u003cdiv data-v-444b0c7e=\"\"\u003e\n\u003cp align=\"justify\"\u003eDuring apoptosis, cells activate specific DNA endonucleases that cleave genomic DNA between nucleosomes. When DNA is extracted from apoptotic cells and analyzed by gel electrophoresis, a characteristic DNA ladder consisting of fragments in multiples of 180–200 bp can be observed.\u003c\/p\u003e\n\u003cp align=\"justify\"\u003eThe TUNEL (TdT-mediated dUTP Nick-End Labeling) Apoptosis Detection Kit (YSFluor™ 640) is designed to detect DNA fragmentation in the nuclei of cells during late-stage apoptosis. The assay is based on the enzymatic activity of Terminal Deoxynucleotidyl Transferase (TdT), which catalyzes the incorporation of YSFluor™ 640-12-dUTP into the 3′-hydroxyl (3′-OH) ends exposed at DNA strand breaks. The labeled DNA can then be detected using a fluorescence microscope or flow cytometer.\u003c\/p\u003e\n\u003cp align=\"justify\"\u003eYSFluor™ 640 is a bright, photostable red-fluorescent dye that provides high signal intensity and excellent resistance to photobleaching.\u003c\/p\u003e\n\u003cp align=\"justify\"\u003eThis kit is broadly applicable and can be used to detect apoptosis in:\u003c\/p\u003e\n\u003cp align=\"justify\"\u003eFormalin-fixed paraffin-embedded (FFPE) tissue sections\u003c\/p\u003e\n\u003cp align=\"justify\"\u003eFrozen tissue sections\u003c\/p\u003e\n\u003cp align=\"justify\"\u003eCultured adherent or suspension cells\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eFeatures\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRapid and Convenient Detection\u003c\/strong\u003e – Simple workflow enables fast assessment of apoptosis in cultured cells without complex procedures.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh Accuracy\u003c\/strong\u003e – Dual staining with Annexin V-YSFluor™ 647 and Propidium Iodide (PI) allows precise discrimination between early apoptotic, late apoptotic, necrotic, and live cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSensitive and Reliable\u003c\/strong\u003e – Optimized fluorophore conjugation and buffer formulation ensure strong signal with minimal background, suitable for flow cytometry and fluorescence microscopy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVersatile\u003c\/strong\u003e – Compatible with a wide range of cell types, including adherent and suspension cells.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eComponents\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ctable style=\"width: 99.9564%; height: 307.972px;\" cellspacing=\"0\" border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 35.5972px;\"\u003e\n\u003ctd style=\"width: 33.5294%; height: 35.5972px;\" valign=\"top\" width=\"171\"\u003e\n\u003cp\u003eComponents No.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 68.6275%; height: 35.5972px;\" valign=\"top\" width=\"350\"\u003e\n\u003cp\u003eName\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"top\" width=\"154\"\u003e\n\u003cp\u003e40308ES20\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"top\" width=\"154\"\u003e\n\u003cp\u003e40308ES50\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"top\" width=\"154\"\u003e\n\u003cp\u003e40308ES60\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 55.1944px;\"\u003e\n\u003ctd style=\"width: 33.5294%; height: 55.1944px;\" valign=\"center\" width=\"171\"\u003e\n\u003cp\u003e40308-A\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 68.6275%; height: 55.1944px;\" valign=\"center\" width=\"350\"\u003e\n\u003cp\u003e5× Equilibration Buffer\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 55.1944px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e750 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 55.1944px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e1.25 mL × 2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 55.1944px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e1.25 mL × 3\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 55.1944px;\"\u003e\n\u003ctd style=\"width: 33.5294%; height: 55.1944px;\" valign=\"center\" width=\"171\"\u003e\n\u003cp\u003e40308-B\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 68.6275%; height: 55.1944px;\" valign=\"center\" width=\"350\"\u003e\n\u003cp\u003eYSFluor™ 640-12-dUTP Labeling Mix\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 55.1944px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e100 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 55.1944px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e250 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 55.1944px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e250 μL × 2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5972px;\"\u003e\n\u003ctd style=\"width: 33.5294%; height: 35.5972px;\" valign=\"center\" width=\"171\"\u003e\n\u003cp\u003e40308-C\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 68.6275%; height: 35.5972px;\" valign=\"center\" width=\"350\"\u003e\n\u003cp\u003eRecombinant TdT Enzyme\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e20 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e50 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e50 μL × 2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5972px;\"\u003e\n\u003ctd style=\"width: 33.5294%; height: 35.5972px;\" valign=\"center\" width=\"171\"\u003e\n\u003cp\u003e40308-D\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 68.6275%; height: 35.5972px;\" valign=\"center\" width=\"350\"\u003e\n\u003cp\u003eProteinase K (2 mg\/mL)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e40 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e100 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e100 μL × 2\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 35.5972px;\"\u003e\n\u003ctd style=\"width: 33.5294%; height: 35.5972px;\" valign=\"center\" width=\"171\"\u003e\n\u003cp\u003e40308-E\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 68.6275%; height: 35.5972px;\" valign=\"center\" width=\"350\"\u003e\n\u003cp\u003eDNase I (1 U\/μL)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e5 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e12 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 35.5972px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e25 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 55.1944px;\"\u003e\n\u003ctd style=\"width: 33.5294%; height: 55.1944px;\" valign=\"center\" width=\"171\"\u003e\n\u003cp\u003e40308-F\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 68.6275%; height: 55.1944px;\" valign=\"center\" width=\"350\"\u003e\n\u003cp\u003e10× DNase I Buffer with MgCl₂\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 55.1944px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e100 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 55.1944px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e250 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 30.1961%; height: 55.1944px;\" valign=\"center\" width=\"154\"\u003e\n\u003cp\u003e500 μL\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003e \u003cstrong\u003eStorage\u003c\/strong\u003e\n\u003c\/h3\u003e\n\u003cp\u003eThis product should be stored at -25℃~-15℃ for one year.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eDocuments:\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eSafety Data Sheet\u003c\/p\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40308-A-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20640)-MSDS-HB220809.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40308-A-TUNEL Apoptosis Detection Kit (Alexa Fluor 640)-MSDS-HB220809.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40308-B-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20640)-MSDS-HB220809.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40308-B-TUNEL Apoptosis Detection Kit (Alexa Fluor 640)-MSDS-HB220809.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40308-C-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20640)-MSDS-HB220809.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40308-C-TUNEL Apoptosis Detection Kit (Alexa Fluor 640)-MSDS-HB220809.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40308-D-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20640)-MSDS-HB220809.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40308-D-TUNEL Apoptosis Detection Kit (Alexa Fluor 640)-MSDS-HB220809.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40308-E-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20640)-MSDS-HB220809.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40308-E-TUNEL Apoptosis Detection Kit (Alexa Fluor 640)-MSDS-HB220809.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv data-v-98c835fc=\"\"\u003e\u003ca title=\"download\" download=\"\" href=\"https:\/\/seas.yeasenbiotech.com\/prod\/doc\/mainDoc\/40308-F-TUNEL%20Apoptosis%20Detection%20Kit%20(Alexa%20Fluor%20640)-MSDS-HB220809.pdf\" data-v-98c835fc=\"\" target=\"_blank\"\u003e\n\u003cp data-v-98c835fc=\"\"\u003e40308-F-TUNEL Apoptosis Detection Kit (Alexa Fluor 640)-MSDS-HB220809.pdf\u003c\/p\u003e\n\u003c\/a\u003e\u003c\/div\u003e\n\u003cp\u003eManuals\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0803\/9419\/1166\/files\/40308ES-Manual-Ver.EN20251111.pdf?v=1762938118\"\u003e40308_Manual_Ver.EN20251111.pdf\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003ePublications Using This Product\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[1] \u003c!--[endif]--\u003eSun X, Peng X, Cao Y, Zhou Y, Sun Y. ADNP promotes neural differentiation by modulating Wnt\/β-catenin signaling. Nat Commun. 2020;11(1):2984. Published 2020 Jun 12. doi:10.1038\/s41467-020-16799-0(IF:11.614)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[2] \u003c!--[endif]--\u003eZhu M, Zhang P, Yu S, et al. Targeting ZFP64\/GAL-1 axis promotes therapeutic effect of nab-paclitaxel and reverses immunosuppressive microenvironment in gastric cancer. J Exp Clin Cancer Res. 2022;41(1):14. Published 2022 Jan 7. doi:10.1186\/s13046-021-02224-x(IF:11.161)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[3] \u003c!--[endif]--\u003eZhang HT, Gui T, Liu RX, et al. Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1. Cell Death Dis. 2021;12(1):121. Published 2021 Jan 25. doi:10.1038\/s41419-021-03416-1(IF:8.469)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[4] \u003c!--[endif]--\u003eChen YJ, Hong WF, Liu ML, et al. An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis. Cell Death Dis. 2022;13(3):237. Published 2022 Mar 14. doi:10.1038\/s41419-022-04692-1(IF:8.469) \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[5] \u003c!--[endif]--\u003eXun Y, Zhou P, Yang Y, et al. Role of Nox4 in High Calcium-Induced Renal Oxidative Stress Damage and Crystal Deposition. Antioxid Redox Signal. 2022;36(1-3):15-38. doi:10.1089\/ars.2020.8159(IF:8.401)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[6] \u003c!--[endif]--\u003eYu W, Zong S, Zhou P, et al. Cochlear Marginal Cell Pyroptosis Is Induced by Cisplatin via NLRP3 Inflammasome Activation. Front Immunol. 2022;13:823439. Published 2022 Apr 20. doi:10.3389\/fimmu.2022.823439(IF:7.561)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[7] \u003c!--[endif]--\u003eDuan X, Huang Y, Chen X, et al. Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis. Oncogenesis. 2021;10(5):38. Published 2021 May 4. doi:10.1038\/s41389-021-00328-9(IF:7.485)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[8] \u003c!--[endif]--\u003eHuang Y, Ma J, Meng Y, et al. Exposure to Oxadiazon-Butachlor causes cardiac toxicity in zebrafish embryos. Environ Pollut. 2020;265(Pt A):114775. doi:10.1016\/j.envpol.2020.114775(IF:6.793)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[9] \u003c!--[endif]--\u003eQiang W, Shen T, Noman M, et al. Fibroblast Growth Factor 21 Augments Autophagy and Reduces Apoptosis in Damaged Liver to Improve Tissue Regeneration in Zebrafish. Front Cell Dev Biol. 2021;9:756743. Published 2021 Oct 22. doi:10.3389\/fcell.2021.756743(IF:6.684)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[10] \u003c!--[endif]--\u003eWu Y, Zhang J, Li C, et al. The Activation of ROS\/NF-κB\/MMP-9 Pathway Promotes Calcium-Induced Kidney Crystal Deposition. Oxid Med Cell Longev. 2021;2021:8836355. Published 2021 Jun 8. doi:10.1155\/2021\/8836355(IF:6.543)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[11] \u003c!--[endif]--\u003eJiang S, Zhang Z, Huang F, et al. Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1\/Nrf2 Pathway. Antioxidants (Basel). 2020;9(8):745. Published 2020 Aug 13. doi:10.3390\/antiox9080745(IF:6.313)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[12] \u003c!--[endif]--\u003eYang P, Yang Y, He X, et al. miR-153-3p Targets βII Spectrin to Regulate Formaldehyde-Induced Cardiomyocyte Apoptosis. Front Cardiovasc Med. 2021;8:764831. Published 2021 Dec 15. doi:10.3389\/fcvm.2021.764831(IF:6.050)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[13] \u003c!--[endif]--\u003eChen YJ, Song HY, Zhang ZW, Chen Q, Tang ZP, Gu M. Extracts of Vine Tea Improve Diet-Induced Non-Alcoholic Steatohepatitis Through AMPK-LXRα Signaling. Front Pharmacol. 2021;12:711763. Published 2021 Jul 30. doi:10.3389\/fphar.2021.711763(IF:5.811)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[14] \u003c!--[endif]--\u003eGong F, Shen T, Zhang J, et al. Nitazoxanide induced myocardial injury in zebrafish embryos by activating oxidative stress response. J Cell Mol Med. 2021;25(20):9740-9752. doi:10.1111\/jcmm.16922(IF:5.310)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[15] \u003c!--[endif]--\u003eZhu D, Wang Z, Zhang G, et al. Periostin promotes nucleus pulposus cells apoptosis by activating the Wnt\/β-catenin signaling pathway. FASEB J. 2022;36(7):e22369. doi:10.1096\/fj.202200123R(IF:5.192)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[16] \u003c!--[endif]--\u003eXu H, Qu C, Gan L, et al. Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice. Hum Mol Genet. 2020;29(10):1624-1634. doi:10.1093\/hmg\/ddaa062(IF:5.101)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[17] \u003c!--[endif]--\u003eLi Q, Qin M, Tan Q, et al. MicroRNA-129-1-3p protects cardiomyocytes from pirarubicin-induced apoptosis by down-regulating the GRIN2D-mediated Ca2+ signalling pathway. J Cell Mol Med. 2020;24(3):2260-2271. doi:10.1111\/jcmm.14908(IF:4.486)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[18] \u003c!--[endif]--\u003eWen Y, Zong S, Liu T, Du P, Li H, Xiao H. Tauroursodeoxycholic acid attenuates cisplatin-induced ototoxicity by inhibiting the accumulation and aggregation of unfolded or misfolded proteins in the endoplasmic reticulum. Toxicology. 2021;453:152736. doi:10.1016\/j.tox.2021.152736(IF:4.221)  \u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e[19] \u003c!--[endif]--\u003eMeng Y, Yin Q, Ma Q, et al. FXII regulates the formation of deep vein thrombosis via the PI3K\/AKT signaling pathway in mice. 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