{"product_id":"txnrd1-antibody-thioredoxin-reductase-1-bha17135953","title":"TXNRD1 Antibody \/ Thioredoxin reductase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTXNRD1 Antibody \/ Thioredoxin reductase 1 is a anti-TXNRD1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TXNRD1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTXNRD1 antibody detects Thioredoxin reductase 1, a selenocysteine-containing enzyme that maintains cellular redox balance by catalyzing the NADPH-dependent reduction of thioredoxin. The UniProt recommended name is Thioredoxin reductase 1 (TXNRD1). This enzyme is a central component of the thioredoxin system, which regulates antioxidant defense, DNA synthesis, and redox signaling.\u003cbr\u003e\u003cbr\u003eFunctionally, TXNRD1 antibody identifies a 654-amino-acid cytosolic enzyme composed of an FAD-binding domain, NADPH-binding domain, and a selenocysteine-containing active site motif (GCUG). TXNRD1 reduces oxidized thioredoxin, which in turn regenerates reduced cysteine residues in target proteins, maintaining redox homeostasis. It also directly reduces lipid hydroperoxides, hydrogen peroxide, and other disulfide-containing molecules, contributing to cellular antioxidant capacity.\u003cbr\u003e\u003cbr\u003eThe TXNRD1 gene is located on chromosome 12q23.3 and encodes the cytosolic isoform of thioredoxin reductase. TXNRD1 expression is regulated by the transcription factor NRF2 through the antioxidant response element (ARE) under oxidative or electrophilic stress. Its activity is essential for maintaining a reducing intracellular environment, supporting cell survival, and modulating signaling pathways such as apoptosis and proliferation.\u003cbr\u003e\u003cbr\u003eIn redox biology, TXNRD1 plays a dual role: it protects cells from oxidative stress yet also supports cancer cell survival under high metabolic demand. Elevated TXNRD1 expression is frequently observed in tumors, where it promotes resistance to chemotherapeutic agents and radiotherapy. Conversely, TXNRD1 inhibition induces oxidative stress, mitochondrial dysfunction, and apoptosis, making it a therapeutic target for cancer and inflammatory diseases.\u003cbr\u003e\u003cbr\u003eBeyond oncology, TXNRD1 contributes to immune function, lipid metabolism, and cardiovascular health. Its deficiency leads to increased susceptibility to oxidative damage, accelerated aging, and metabolic imbalance. In experimental models, altered TXNRD1 expression affects insulin sensitivity and lipid peroxidation levels, linking it to metabolic and neurodegenerative disorders.\u003cbr\u003e\u003cbr\u003eTXNRD1 antibody is widely used in redox biology, metabolism, and cancer research. It is suitable for western blotting, immunohistochemistry, and enzymatic assays to monitor TXNRD1 expression and activity. This antibody supports investigations into antioxidant defense, redox signaling, and selenoprotein regulation. In pharmacology, it helps evaluate TXNRD1 as a biomarker of oxidative stress and drug response.\u003cbr\u003e\u003cbr\u003eStructurally, TXNRD1 forms a homodimer with active sites on each subunit and utilizes FAD and NADPH cofactors for electron transfer. Its C-terminal selenocysteine residue is critical for catalytic turnover.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TXNRD1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TXNRD1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TXNRD1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TXNRD1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TXNRD1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047310680429,"sku":"FY13051","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_eaf34e55-1efb-4134-88d1-d12b7176dc1b.jpg?v=1782237069","url":"https:\/\/www.ebiohippo.com\/products\/txnrd1-antibody-thioredoxin-reductase-1-bha17135953","provider":"BioHippo","version":"1.0","type":"link"}