{"product_id":"tyrp1-antibody-tyrosinase-related-protein-1-bha17136102","title":"TYRP1 Antibody \/ Tyrosinase-related protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eTYRP1 Antibody \/ Tyrosinase-related protein 1 is a anti-TYRP1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm (Melanosome).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e TYRP1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eTYRP1 antibody detects Tyrosinase-related protein 1, a melanogenic enzyme that participates in the biosynthesis of melanin within pigment-producing cells. The UniProt recommended name is Tyrosinase-related protein 1 (TYRP1, TRP1). This enzyme functions in the melanosome maturation process, catalyzing oxidation reactions that determine the type and intensity of pigmentation in skin, hair, and eyes. TYRP1 is one of three core melanogenic enzymes, working in coordination with tyrosinase (TYR) and dopachrome tautomerase (DCT).\u003cbr\u003e\u003cbr\u003eFunctionally, TYRP1 antibody identifies a 537-amino-acid type I transmembrane glycoprotein localized to melanosomal membranes. TYRP1 contributes to the oxidative conversion of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) during eumelanin synthesis and stabilizes the activity of tyrosinase through protein-protein interactions. It plays a central role in regulating pigmentation intensity, melanosome biogenesis, and melanocyte survival. In addition, TYRP1 acts as an antioxidant enzyme, protecting pigment cells from oxidative stress generated during melanin production.\u003cbr\u003e\u003cbr\u003eThe TYRP1 gene is located on chromosome 9p23 and is specifically expressed in melanocytes and retinal pigment epithelial cells. Its expression is tightly regulated by the microphthalmia-associated transcription factor (MITF), which coordinates the transcriptional program of melanogenesis. TYRP1 expression levels and genetic polymorphisms contribute to pigment variation among populations and species.\u003cbr\u003e\u003cbr\u003ePathologically, mutations in TYRP1 cause oculocutaneous albinism type 3 (OCA3), characterized by reduced pigmentation and visual abnormalities. Altered TYRP1 expression has also been associated with melanoma progression, where it influences tumor cell differentiation and immune recognition. Research using TYRP1 antibody supports studies in pigmentation biology, melanosome formation, and melanoma immunology.\u003cbr\u003e\u003cbr\u003eTYRP1 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect melanosomal proteins. \u003cbr\u003e\u003cbr\u003eStructurally, Tyrosinase-related protein 1 contains a luminal catalytic domain with two copper-binding sites and multiple glycosylation motifs that ensure enzymatic stability and trafficking. Its C-terminal transmembrane region anchors it to melanosomal membranes, while its N-terminal signal sequence directs localization to the secretory pathway. This antibody enables investigation of TYRP1's role in melanin biosynthesis, pigment cell regulation, and disease mechanisms affecting coloration.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=TYRP1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=TYRP1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=TYRP1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/TYRP1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=TYRP1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047319298413,"sku":"FY13200","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fa2fa083-4856-4b71-be07-5858f2534c4c.jpg?v=1782237074","url":"https:\/\/www.ebiohippo.com\/products\/tyrp1-antibody-tyrosinase-related-protein-1-bha17136102","provider":"BioHippo","version":"1.0","type":"link"}