{"product_id":"u-blot-pan-asymmetric-di-methyl-arginine-rabbit-mab-bha21821327","title":"U-Blot® Pan-Asymmetric Di-Methyl Arginine Rabbit mAb","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003ePost-Translational Modification Antibody\u003c\/span\u003e\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eU-Blot® Pan-Asymmetric Di-Methyl Arginine Rabbit mAb is a recombinant monoclonal antibody raised in Rabbit that specifically recognizes \u003cstrong\u003eAsymmetric Di-Methyl Arginine\u003c\/strong\u003e (Asymmetric dimethylation of arginine [Arg(R)]). It is designed for detection and analysis of the Asymmetric dimethylation of arginine [Arg(R)] post-translational modification across research applications.\u003c\/p\u003e\n\u003cp\u003eHistones and non-histone proteins undergo diverse enzyme-catalyzed post-translational modifications, including methylation, acetylation, phosphorylation and ubiquitination. Asymmetric dimethyl arginine (ADMA) is a classic arginine methylation modification, catalyzed mainly by type I protein arginine methyltransferases (PRMTs).ADMA modification is widely distributed in eukaryotic cells and enriched in chromatin-associated proteins, RNA-binding proteins and signaling molecules. It participates in regulating chromatin remodeling, gene transcription, RNA splicing, DNA damage repair and cell cycle progression.Abnormal ADMA level is closely associated with metabolic disorders, inflammatory response, tumor occurrence and progression, as well as cardiovascular and neurodegenerative diseases. It has become an important molecular marker and research target for epigenetic regulation and disease mechanism study.\u003c\/p\u003e\n\u003ch2\u003eValidated Applications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eApplication\u003c\/th\u003e\n\u003ctd\u003eWestern Blot\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eRecommended Dilution\u003c\/th\u003e\n\u003ctd\u003eWB 1:500-1000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eHost\u003c\/th\u003e\n\u003ctd\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003eRecombinant Monoclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eIsotype\u003c\/th\u003e\n\u003ctd\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eReactivity\u003c\/th\u003e\n\u003ctd\u003eHuman, Mouse, Rat\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eConjugate\u003c\/th\u003e\n\u003ctd\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurification\u003c\/th\u003e\n\u003ctd\u003eProtein A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003eCalculated: Multiple | Observed: Multiple\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eImmunogen \/ Antigen\u003c\/h2\u003e\n\u003cp\u003epolypeptide\u003c\/p\u003e\n\u003ch2\u003eReactivity Notes\u003c\/h2\u003e\n\u003cp\u003eThis antibody shows reactivity with Human, Mouse, Rat. It targets the Asymmetric dimethylation of arginine [Arg(R)] modification and is suitable for Western Blot.\u003c\/p\u003e\n\u003cdiv class=\"bhp-qc-badge\"\u003eValidated for Western Blot\u003c\/div\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\n\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for diagnostic or therapeutic use. Store at -20°C. Avoid repeated freeze-thaw cycles | Stable for 12 months from date of receipt \/ reconstitution.\u003c\/div\u003e\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eExplore other UcallM Biosciences post-translational modification antibodies available through BioHippo.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"UcallM Biosciences Inc","offers":[{"title":"100 uL","offer_id":53438913610093,"sku":"WT9041R-100UL","price":550.0,"currency_code":"USD","in_stock":true},{"title":"300 uL","offer_id":53438913642861,"sku":"WT9041R-300UL","price":1400.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Ucallm_WT9041R-100.jpg?v=1781281838","url":"https:\/\/www.ebiohippo.com\/products\/u-blot-pan-asymmetric-di-methyl-arginine-rabbit-mab-bha21821327","provider":"BioHippo","version":"1.0","type":"link"}