{"product_id":"u-blot-pan-tri-methyllysine-rabbit-pab-klh-conjugate-immunogen-bha21821428","title":"U-Blot® Pan-Tri-Methyllysine Rabbit pAb (KLH-conjugate immunogen)","description":"\u003cdiv class=\"bhp-desc\"\u003e\n\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\u003c\/style\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003ePost-Translational Modification Antibody\u003c\/span\u003e\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eU-Blot® Pan-Tri-Methyllysine Rabbit pAb (KLH-conjugate immunogen) is a polyclonal antibody raised in Rabbit that specifically recognizes \u003cstrong\u003eTri-Methyllysine\u003c\/strong\u003e (Lysine trimethylation [Lys(K)]). It is designed for detection and analysis of the Lysine trimethylation [Lys(K)] post-translational modification across research applications.\u003c\/p\u003e\n\u003cp\u003eHistones undergo a wide range of enzyme-catalyzed post-translational modifications, including acetylation, methylation, phosphorylation and ubiquitination. Lysine trimethylation is a vital epigenetic modification that predominantly occurs on histone lysine residues. It is dynamically regulated by histone methyltransferases and demethylases, and extensively distributed in eukaryotic chromatin.Lysine trimethylation participates in governing chromatin structure remodeling, transcriptional activation or repression, cell cycle regulation, and DNA damage repair. Abnormal trimethylation levels are closely associated with tumorigenesis, developmental disorders, inflammation and neurodegenerative diseases, acting as a pivotal molecular marker for epigenetic research and disease mechanism investigation.\u003c\/p\u003e\n\u003ch2\u003eValidated Applications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eApplication\u003c\/th\u003e\n\u003ctd\u003eELISA, Western Blot, Immunoprecipitation, Immunofluorescence, Immunoaffinity Chromatography\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eRecommended Dilution\u003c\/th\u003e\n\u003ctd\u003eELISA 1:2000, WB 1:2000, IP 5 ug\/mg protein sample, IF 5 ug\/mL or 1:100\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eHost\u003c\/th\u003e\n\u003ctd\u003eRabbit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eClonality\u003c\/th\u003e\n\u003ctd\u003ePolyclonal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eIsotype\u003c\/th\u003e\n\u003ctd\u003eIgG\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eReactivity\u003c\/th\u003e\n\u003ctd\u003eSpecies Independent\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eConjugate\u003c\/th\u003e\n\u003ctd\u003eUnconjugated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003ePurification\u003c\/th\u003e\n\u003ctd\u003eN-(epsilon) trimethyllysine on agarose and immunoaffinity absorbed with N-(epsilon) methylated lysine and N-(epsilon) dimethylated lysine on agarose\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eMolecular Weight\u003c\/th\u003e\n\u003ctd\u003eCalculated: Multiple | Observed: Multiple\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eImmunogen \/ Antigen\u003c\/h2\u003e\n\u003cp\u003eMethylated KLH conjugates\u003c\/p\u003e\n\u003ch2\u003eReactivity Notes\u003c\/h2\u003e\n\u003cp\u003eThis antibody shows reactivity with Species Independent. It targets the Lysine trimethylation [Lys(K)] modification and is suitable for ELISA, Western Blot, Immunoprecipitation, Immunofluorescence, Immunoaffinity Chromatography.\u003c\/p\u003e\n\u003cdiv class=\"bhp-qc-badge\"\u003eValidated for ELISA\u003c\/div\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003e\n\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for diagnostic or therapeutic use. Product is stable for several weeks at 4°C. For extended storage, store product at -20ºC. | Stable for 12 months from date of receipt \/ reconstitution.\u003c\/div\u003e\n\u003ch2\u003eRelated Products\u003c\/h2\u003e\n\u003cp\u003eExplore other UcallM Biosciences post-translational modification antibodies available through BioHippo.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"UcallM Biosciences Inc","offers":[{"title":"100 uL","offer_id":53438911644013,"sku":"WT9182-100UL","price":750.0,"currency_code":"USD","in_stock":true},{"title":"300 uL","offer_id":53438911676781,"sku":"WT9182-300UL","price":1950.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Ucallm_WT9182-100.jpg?v=1781281837","url":"https:\/\/www.ebiohippo.com\/products\/u-blot-pan-tri-methyllysine-rabbit-pab-klh-conjugate-immunogen-bha21821428","provider":"BioHippo","version":"1.0","type":"link"}