{"product_id":"u0126-bhb11900168","title":"U0126","description":"\u003cp\u003eU-0126 is a selective and non-competitive inhibitor of MEK1 and MEK2 (IC50 = 72 nM and 58 nM, respectively), key kinases in the MAPK\/ERK signaling cascade. This pathway regulates cell proliferation, differentiation, and survival—processes often dysregulated in neurodegenerative diseases. U-0126 is widely used in neuroscience to investigate ERK-dependent mechanisms of synaptic plasticity, memory formation, and neuronal survival. It also inhibits AP-1 transcriptional activity and suppresses the production of inflammatory cytokines and matrix metalloproteinases, linking it to studies on neuroinflammation and glial activation. U-0126’s ability to induce apoptosis under growth factor deprivation conditions further supports its use in modeling neurodegenerative stress responses. Its fluorescence properties in cell culture also make it a useful marker in imaging-based assays.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"5 mg","offer_id":53040946839917,"sku":"SIH-380-5MG","price":170.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040967483757,"sku":"SIH-380-25MG","price":737.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-380_U-0126_Chemical_Structure.png?v=1771837642","url":"https:\/\/www.ebiohippo.com\/products\/u0126-bhb11900168","provider":"BioHippo","version":"1.0","type":"link"}