{"product_id":"ufd1l-antibody-ubiquitin-fusion-degradation-1-like-bha17136079","title":"UFD1L Antibody \/ Ubiquitin Fusion Degradation 1 Like","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eUFD1L Antibody \/ Ubiquitin Fusion Degradation 1 Like is a anti-UFD1L Rabbit antibody Recombinant Rabbit Monoclonal clone 29U95 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e UFD1L\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29U95, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eUFD1L antibody detects Ubiquitin fusion degradation protein 1 like, encoded by the UFD1L gene. Ubiquitin fusion degradation protein 1 like forms a complex with NPL4 and the ATPase p97\/VCP to regulate extraction of ubiquitinated substrates from membranes and protein complexes. This activity is essential for protein quality control, endoplasmic reticulum associated degradation, and mitotic progression. UFD1L antibody provides researchers with an important tool for studying ubiquitin signaling, proteostasis, and cell cycle regulation.\u003cbr\u003e\u003cbr\u003eThe UFD1L-NPL4-p97 complex functions as a segregase, using ATP hydrolysis to unfold and extract ubiquitinated proteins for degradation by the proteasome. Research using UFD1L antibody has demonstrated that this complex acts in multiple pathways, including clearance of misfolded proteins from the endoplasmic reticulum, disassembly of protein aggregates, and regulation of spindle assembly during mitosis. Its versatile roles make UFD1L a central hub in protein quality control networks.\u003cbr\u003e\u003cbr\u003eMutations and deletions involving UFD1L are associated with genetic disorders. Studies with UFD1L antibody have shown that haploinsufficiency contributes to DiGeorge syndrome, a developmental disorder characterized by congenital heart defects, immune dysfunction, and craniofacial anomalies. Because UFD1L is located in the 22q11 region, deletions that remove this gene disrupt proteostasis during development, contributing to disease phenotypes.\u003cbr\u003e\u003cbr\u003eIn cancer biology, UFD1L has been implicated in regulating cell proliferation and survival. Research using UFD1L antibody has revealed that overexpression enhances proteasomal degradation of regulatory proteins, supporting uncontrolled growth. Conversely, loss of function can cause accumulation of toxic aggregates, impairing viability. These dual roles highlight its importance in maintaining balanced proteostasis across different contexts.\u003cbr\u003e\u003cbr\u003eUFD1L antibody is widely used in western blotting, immunohistochemistry, and immunoprecipitation. Western blotting identifies endogenous levels, immunohistochemistry localizes expression in developmental tissues, and immunoprecipitation demonstrates interactions with p97\/VCP and NPL4. These applications make UFD1L antibody essential in both developmental and disease research.\u003cbr\u003e\u003cbr\u003eBy supplying validated UFD1L antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=UFD1L - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=UFD1L - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=UFD1L - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/UFD1L - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=UFD1L+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047314874733,"sku":"FY13177","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e5401648-6bfa-4c61-8224-639ff0a7f5e3.jpg?v=1772019405","url":"https:\/\/www.ebiohippo.com\/products\/ufd1l-antibody-ubiquitin-fusion-degradation-1-like-bha17136079","provider":"BioHippo","version":"1.0","type":"link"}