{"product_id":"ulbp1-antibody-ul16-binding-protein-1-bha17135237","title":"ULBP1 Antibody \/ UL16-binding protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eULBP1 Antibody \/ UL16-binding protein 1 is a anti-ULBP1 Rabbit antibody Recombinant Rabbit Monoclonal clone 30U90 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ULBP1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 30U90, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eULBP1 antibody is designed to detect UL16-binding protein 1, a stress-induced ligand for the NKG2D receptor on natural killer (NK) cells and certain T cells. ULBP1 is a member of the MHC class I-related family of proteins that are not involved in antigen presentation but instead act as activating ligands for immune recognition. Expression of ULBP1 is upregulated in response to infection, cellular stress, and transformation, making it an important component of immune surveillance.\u003cbr\u003e\u003cbr\u003eULBP1 antibody is widely applied in immunology, cancer biology, and infectious disease research. By detecting ULBP1, researchers can investigate how cells communicate danger signals to the immune system and how tumors or viruses evade recognition. In many cancers, ULBP1 expression is altered, leading to reduced activation of NK cells and impaired immune clearance. Similarly, viruses such as cytomegalovirus encode proteins that bind and inhibit ULBP1, preventing immune detection. ULBP1 antibody enables researchers to study these interactions in detail.\u003cbr\u003e\u003cbr\u003eThe antibody is suitable for western blotting, immunohistochemistry, flow cytometry, and immunofluorescence. In flow cytometry, ULBP1 antibody detects cell surface expression, allowing quantitative analysis of NKG2D ligand expression on different cell types. Immunohistochemistry provides localization in tissue sections, while immunofluorescence allows colocalization with other markers of stress response or immune activity. These versatile applications support broad investigations of immune recognition pathways.\u003cbr\u003e\u003cbr\u003eULBP1 is particularly important in tumor immunology. Upregulation of ULBP1 on cancer cells should, in principle, trigger immune clearance by NK cells and cytotoxic T lymphocytes. However, many tumors adopt strategies to shed ULBP1 or modulate its expression, thereby escaping immune attack. By employing ULBP1 antibody, researchers can study how these immune evasion strategies develop and assess approaches to restore immune recognition.\u003cbr\u003e\u003cbr\u003eBeyond cancer, ULBP1 antibody is relevant to infection biology. Viral immune evasion strategies often involve downregulating or inhibiting stress ligands like ULBP1. Monitoring these changes provides insight into how pathogens adapt to host immune defenses. In autoimmune disease, inappropriate expression of ULBP1 may contribute to immune dysregulation, making it a focus of research into pathological inflammation.\u003cbr\u003e\u003cbr\u003eULBP1 antibody offered by\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ULBP1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ULBP1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ULBP1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ULBP1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ULBP1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047286825325,"sku":"FY12334","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_13aefded-1b9d-4cc7-be77-25e992374c60.jpg?v=1772019281","url":"https:\/\/www.ebiohippo.com\/products\/ulbp1-antibody-ul16-binding-protein-1-bha17135237","provider":"BioHippo","version":"1.0","type":"link"}