{"product_id":"valeryl-coenzyme-a-free-acid-bhb21200014","title":"Valeryl Coenzyme A, Free acid","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003eValeryl Coenzyme A, free acid is a biochemical supplied by Coenza for use in enzymology and metabolic research. Available as Lyophilized powder, purity ≥ 95%, suitable for in vitro assays and pathway studies.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAlso known as:\u003c\/em\u003e Pentanoyl coenzyme A, Valeryl-CoA, n-Valeryl-CoA.\u003c\/p\u003e\n\u003ch2\u003eKey Elements and Design Rationale\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula \/ MW \/ Purity:\u003c\/strong\u003e C26H44N7O17P3S; 851.65 g\/mol; ≥ 95%. The Free Acid form provides enhanced aqueous stability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm \/ Solubility:\u003c\/strong\u003e Lyophilized powder; Soluble in water.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynonyms:\u003c\/strong\u003e Pentanoyl coenzyme A, Valeryl-CoA, n-Valeryl-CoA.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrigin:\u003c\/strong\u003e Synthetic synthesis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eBiological Background\u003c\/h2\u003e\n\u003cp\u003eValeryl-CoA is a thioester derivative of Coenzyme A involved in fatty acid metabolism. As a medium-chain acyl-CoA, it serves as an intermediate in various metabolic pathways, including the oxidation and elongation of fatty acids and the biosynthesis of complex lipids. Valeryl-CoA is also a substrate for several enzymes involved in energy production and cellular signaling. Its reactive acyl group allows it to participate in diverse biochemical reactions, playing a critical role in cellular energy homeostasis and metabolic regulation (Ellis et al., 2021; Liu et al., 2013).ApplicationsValeryl CoA, Free Acid, is widely utilized in metabolic research to study fatty acid oxidation and chain elongation processes. It is particularly valuable for examining the role of medium-chain fatty acid metabolism in energy production and cellular function. Researchers use Valeryl-CoA Free Acid in in vitro assays to investigate enzyme kinetics, metabolic flux, and regulatory mechanisms of CoA derivatives in both normal and pathological states (Ellis et al., 2021; Spry et al., 2008). Its involvement in lipid metabolism makes it an important reagent for developing therapeutic strategies for metabolic dis\u003c\/p\u003e\n\u003ch2\u003eResearch Relevance and Current Trends\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAcyl-CoA metabolism increasingly linked to histone acylation marks and epigenetic regulation in cancer and metabolic disease research.\u003c\/li\u003e\n\u003cli\u003eGrowing interest in short-chain fatty acid CoA thioesters as mediators of gut microbiome–host metabolic crosstalk.\u003c\/li\u003e\n\u003cli\u003eCoA-dependent enzymes investigated as drug targets in infectious disease and neurometabolic disorder research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCommon Research Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eEnzyme kinetics assays — direct substrate for acyltransferases, thiolases, and dehydrogenases.\u003c\/li\u003e\n\u003cli\u003eMetabolic flux analysis — isotope-labeled variants available for stable-isotope tracing.\u003c\/li\u003e\n\u003cli\u003eIn vitro pathway reconstitution for fatty acid β-oxidation, TCA cycle, or polyketide biosynthesis.\u003c\/li\u003e\n\u003cli\u003eBiochemical characterization of CoA-binding proteins by activity assays or binding measurements.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eNotes for Experimental Interpretation\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCoA thioesters hydrolyze at neutral–alkaline pH; prepare working solutions fresh and keep on ice.\u003c\/li\u003e\n\u003cli\u003eDifferent salt forms share the same core structure — normalize concentrations using the free-acid MW when comparing across forms.\u003c\/li\u003e\n\u003cli\u003eThiol oxidation may occur upon air exposure; use under inert atmosphere or with reducing agents where appropriate.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Coenza","offers":[{"title":"10 mg","offer_id":53249725923693,"sku":"A-11-10MG","price":363.7,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/fc74bc_085995be45744a319a76d846ce1efc3e_mv2.png?v=1776855585","url":"https:\/\/www.ebiohippo.com\/products\/valeryl-coenzyme-a-free-acid-bhb21200014","provider":"BioHippo","version":"1.0","type":"link"}