{"product_id":"vegfr2-antibody-bha17103846","title":"VEGFR2 Antibody","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eVEGFR2 antibody supplied as a ascites reagent for IHC-F in Human samples. This product is a monoclonal (mouse origin) antibody (host: Mouse; isotype: Mouse IgG1) intended for research use only. The target is commonly annotated with cytoplasmic and cell surface localization context, which may inform staining patterns.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Monoclonal (mouse origin); host Mouse; isotype Mouse IgG1; clone KDR-1.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eFormat and purification:\u003c\/strong\u003e format: Ascites; purity: Unpurified ascites.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity (reported):\u003c\/strong\u003e Human.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eApplications (listed):\u003c\/strong\u003e IHC-F.\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eImmunogen \/ epitope context:\u003c\/strong\u003e Recombinant human extracellular domain of VEGFR-2(KDR) was used as the immunogen for this VEGFR2 antibody..\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eLocalization:\u003c\/strong\u003e Cytoplasmic and cell surface (annotation-level guidance; cell state and isoforms can shift patterns).\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese attributes help you align the antibody with the biological question (target state, sample type, and readout) while keeping interpretation grounded in appropriate controls.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eVEGFR2 is the intended antigen for this primary antibody. Reported biological context includes: VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. The importance of VEGF and its receptor system in tumor growth and intervention in this system may provide promising approaches to cancer therapy. Subcellular localization information (Cytoplasmic and cell surface) can be useful when interpreting IF\/ICC patterns and selecting compartment-enriched lysates for WB.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003ePost-translational modification mapping: phosphorylation-site–resolved antibodies are used to connect signaling inputs to target activation states and downstream readouts.\u003c\/li\u003e   \u003cli\u003eSignal-flow and turnover studies: researchers pair immunodetection with perturbations that modulate enzymatic activity or proteostasis to understand regulation, stability, and feedback.\u003c\/li\u003e   \u003cli\u003eSpatial and single-cell approaches: imaging-based and cytometry workflows increasingly quantify heterogeneity and relocalization rather than only bulk abundance.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eIHC-F: commonly used to measure relative target levels or localization changes in the context of the experimental question.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eAcross these readouts, differences in signal intensity, localization, or complex enrichment are typically interpreted alongside sample-matched controls and independent evidence to distinguish regulation from technical variation.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e   \u003cli\u003eIsoforms, cleavage products, or post-translational modifications can alter apparent molecular weight and subcellular distribution; interpret bands and staining patterns in the context of expected biology and sample preparation.\u003c\/li\u003e   \u003cli\u003eSpecies differences and epitope conservation may affect binding; use matched positive controls and orthogonal evidence when comparing across organisms.\u003c\/li\u003e   \u003cli\u003eControl concepts: include appropriate isotype and secondary-only controls (for imaging), and consider genetic perturbations (knockout\/knockdown\/overexpression) or independent antibodies targeting distinct epitopes to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEpitope context is defined by the immunogen description; when available, align this with known domains, PTM sites, or family homology to anticipate potential cross-reactivity patterns. As a monoclonal antibody, binding is driven by a single epitope, which can support consistent recognition but may be sensitive to epitope masking by PTMs or conformational changes.\u003c\/p\u003e \u003c!-- Sources (internal): - NCBI Gene search (VEGFR2) — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=VEGFR2 - Ensembl search (VEGFR2) — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=VEGFR2 - PubMed search (VEGFR2) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=VEGFR2 - Reactome pathway search (VEGFR2) — Reactome — https:\/\/reactome.org\/content\/query?q=VEGFR2 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml with 1% BSA and 0.01% sodium azide if reconstituted with 0.2ml sterile 1X PBS \/ 100 ug","offer_id":53043251380589,"sku":"R30035","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_526702d5-22bb-4034-a3ac-9327579879d7.jpg?v=1771934453","url":"https:\/\/www.ebiohippo.com\/products\/vegfr2-antibody-bha17103846","provider":"BioHippo","version":"1.0","type":"link"}