{"product_id":"veratridine-bhb21300365","title":"Veratridine","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 71-62-5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C36H51NO11.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;98%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1-200 μM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Various NaV Na+ channels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Natural\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e Veratridine is an alkaloid which is a potent modulator of voltage-dependent Na+ channels and hence, of transmitter release1,2. Veratridine reduces the single channel conductance and increases the persistent opening probability3.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eVeratridine is an alkaloid extracted from the Veratrum officinale plant. It is a potent modulator of voltage-dependent Na+ channels and hence, of transmitter release1,2. Veratridine reduces the single channel conductance and increases the persistent opening probability of NaV1.4 channels expressed in a mammalian cell line3. Veratridine affects differentially the TTX-sensitive and TTX-resistant components of NaV currents in rat DRG neurons. Although veratridine inhibits both components at the peak current, it is much more effective in increasing the persistent component (channel opening) of the TTX-sensitive current4. Veratridine is widely used in different excitable preparations to induce NaV channel dependent transmitter release (see for example reference #5).\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249715405165,"sku":"V-110-10MG-1","price":103.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311579521389,"sku":"V-110-25MG-1","price":211.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311579554157,"sku":"V-110-5MG-1","price":81.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311579586925,"sku":"V-110-50MG-1","price":358.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/V-110_gr.gif?v=1778544458","url":"https:\/\/www.ebiohippo.com\/products\/veratridine-bhb21300365","provider":"BioHippo","version":"1.0","type":"link"}