{"product_id":"vglut1-antibody-vesicular-glutamate-transporter-1-bha17128452","title":"VGLUT1 Antibody \/ Vesicular glutamate transporter 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eVGLUT1 Antibody \/ Vesicular glutamate transporter 1 is an antibody targeting \u003cstrong\u003eVGLUT1\u003c\/strong\u003e, raised in \u003cstrong\u003eGoat\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e VGLUT1.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (goat origin); Goat Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e IHC-P, ELISA (peptide) (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eVGLUT1 (Vesicular glutamate transporter 1), also called SLC17A7 and BNPI (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) is responsible for packaging glutamate, the most abundant neurotransmitter in the brain, into synaptic vesicles. These vesicles then release glutamate into the synapse, where it binds to receptors on the postsynaptic neuron, triggering a cascade of events that ultimately lead to the transmission of signals. Without VGLUT1, this process would be disrupted, leading to impaired neurotransmission and potentially affecting brain function. Research has shown that abnormalities in VGLUT1 expression are associated with various neurological disorders, including schizophrenia, Alzheimer's disease, and epilepsy.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eImmunohistochemistry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eELISA: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q9P2U7 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q9P2U7 - Gene search: VGLUT1 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=VGLUT1 - Ensembl search: VGLUT1 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=VGLUT1 - PubMed search: VGLUT1 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=VGLUT1+antibody - Reactome search: VGLUT1 — Reactome — https:\/\/reactome.org\/content\/query?q=VGLUT1 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5 mg\/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide \/ 100 ug","offer_id":53046420668781,"sku":"R36504-100UG","price":475.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_daea6b8a-737f-4a49-9d60-bb79480d5ebc.jpg?v=1772000541","url":"https:\/\/www.ebiohippo.com\/products\/vglut1-antibody-vesicular-glutamate-transporter-1-bha17128452","provider":"BioHippo","version":"1.0","type":"link"}