{"product_id":"vps35-elisa-kit-bhe11900049","title":"MOLECULAR SIGNATURE® VPS35 ELISA Kit","description":"\u003cp\u003eVacuolar Protein Sorting 35 (VPS35) is a core component of the retromer complex, which mediates the recycling of membrane proteins from endosomes to the Golgi apparatus. VPS35 plays a critical role in maintaining neuronal protein homeostasis, synaptic function, and mitochondrial integrity.  Mutations in VPS35, particularly the D620N variant, have been directly linked to familial Parkinson’s disease. These mutations impair retromer function, leading to defective trafficking of key neuronal receptors and enzymes, increased protein aggregation, and mitochondrial fragmentation.  In neurodegeneration research, VPS35 is a focal point for understanding how intracellular transport defects contribute to dopaminergic neuron loss. Targeting retromer dysfunction offers a promising therapeutic strategy for modifying disease progression in Parkinson’s and related disorders.\u003c\/p\u003e \u003cul\u003e   \u003cli\u003e\n\u003cstrong\u003ePlatform:\u003c\/strong\u003e Microplate\u003c\/li\u003e   \u003cli\u003e\n\u003cstrong\u003eIncubation Time:\u003c\/strong\u003e 3 hours\u003c\/li\u003e \u003c\/ul\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"96 well","offer_id":53047418683757,"sku":"SKT-141-96","price":624.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SKT-141_VPS35_Kit_Typical_Standard_Curve-1-1.png?v=1782159108","url":"https:\/\/www.ebiohippo.com\/products\/vps35-elisa-kit-bhe11900049","provider":"BioHippo","version":"1.0","type":"link"}