{"product_id":"vuf-10166-bhb21300366","title":"VUF 10166","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 155584-74-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C13H15Cl2N4.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.05 nM - 100 nM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e 5-Hydroxytryptamine Receptor 3A and 3B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e VUF 10166 is a potent and selective 5-HT3A and B receptor antagonist1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eVUF 10166 is a potent and selective antagonist of 5-HT3A and B receptors. It binds specifically and with high affinity to 5-HT3A (IC50 ~ 0.04 nM) and blocks the serotonin binding site. There's evidence of lower affinity to 5-HT3A\/B receptors due to the influence of an additional allosteric binding site in the heteromer2.VUF 10166 is able to bind to an orthosteric binding site of HT3A and 5-HT3A\/B receptors - A+A− and an A+B− interface. binding to the A+B− interface in the 5-HT3A\/B receptor may decrease the affinity of ligands binding to the A+A− site by allosterically increasing the rate of ligand dissociation from the adjacent orthosteric site1,3.The 5-HT3 receptor subtype is a member of the Cys-loop ligand-gated cation channels which are expressed throughout the central and peripheral nervous systems and mediates a variety of physiological functions4.Competitive antagonists of 5-HT3 receptors are used to treat symptoms of emesis arising from chemotherapy treatment and postoperative emesis after anesthesia and surgery. There is also a limited use of antagonists for treating irritable bowel syndrome2.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249715306861,"sku":"V-115-10MG-1","price":85.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311581487469,"sku":"V-115-25MG-1","price":168.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311581520237,"sku":"V-115-5MG-1","price":66.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311581553005,"sku":"V-115-50MG-1","price":323.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/V-115_gr.gif?v=1778544457","url":"https:\/\/www.ebiohippo.com\/products\/vuf-10166-bhb21300366","provider":"BioHippo","version":"1.0","type":"link"}