{"product_id":"wdr26-antibody-wd-repeat-domain-containing-protein-26-bha17135728","title":"WDR26 Antibody \/ WD repeat domain-containing protein 26","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eWDR26 Antibody \/ WD repeat domain-containing protein 26 is a anti-WDR26 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Nuclear, cytoplasmic.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e WDR26\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eWDR26 antibody detects WD repeat domain-containing protein 26, a multifunctional adaptor protein that participates in G protein-coupled receptor (GPCR) signaling, cytoskeletal regulation, and cell proliferation. Encoded by the WDR26 gene on chromosome 1q42.11, this protein contains several WD40 repeats that form a beta-propeller structure facilitating protein-protein interactions. WDR26 functions as a scaffold that coordinates signal transduction and cytoskeletal rearrangements downstream of heterotrimeric G proteins and growth factor receptors.\u003cbr\u003e\u003cbr\u003eWDR26 localizes to both the cytoplasm and plasma membrane, where it binds Gbetagamma subunits and regulates downstream effectors such as PI3K, AKT, and ERK. By modulating these pathways, it controls cell migration, survival, and proliferation. Additionally, WDR26 plays roles in vesicle trafficking, stress response, and cell morphology through interactions with actin-associated proteins.\u003cbr\u003e\u003cbr\u003eThe WDR26 antibody is used in signaling, oncology, and molecular biology research to investigate scaffolding functions and GPCR-mediated pathways. Western blot analysis identifies a 65 kilodalton band corresponding to WDR26, while immunofluorescence shows cytoplasmic and membrane-associated staining. This antibody supports the study of protein complexes that regulate cellular communication and structure.\u003cbr\u003e\u003cbr\u003eAberrant expression of WDR26 has been linked to cancer progression and inflammatory signaling. Elevated WDR26 enhances AKT phosphorylation and cell survival, contributing to chemoresistance and metastasis, while loss of expression disrupts signaling coordination. The WDR26 antibody provides a valuable tool for exploring these mechanisms in disease and cellular physiology.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=WDR26 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=WDR26 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=WDR26 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/WDR26 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=WDR26+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047303962989,"sku":"FY12826","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e912018b-90e1-4e0c-8aaf-874303d1e066.jpg?v=1782237049","url":"https:\/\/www.ebiohippo.com\/products\/wdr26-antibody-wd-repeat-domain-containing-protein-26-bha17135728","provider":"BioHippo","version":"1.0","type":"link"}