{"product_id":"wisp-2-antibody-wnt1-inducible-signaling-pathway-protein-2-ccn5-bha17128151","title":"WISP-2 Antibody \/ WNT1-inducible-signaling pathway protein 2 \/ CCN5","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eWISP-2 Antibody \/ WNT1-inducible-signaling pathway protein 2 \/ CCN5 is an antibody targeting \u003cstrong\u003eWISP-2\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e WISP-2.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, IHC-P (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eCCN5, also known as WISP-2 (Wnt-1-induced secreted protein 2), is a member of the CCN family of proteins that are involved in cell growth, differentiation, and migration. It is known for its ability to modulate signaling pathways that regulate various cellular activities, making it a key player in maintaining homeostasis in tissues. One of the primary functions of CCN5 is its role in regulating the growth and development of tissues, particularly in the cardiovascular system. Studies have shown that CCN5 can protect against cardiac fibrosis and hypertrophy, making it a potential therapeutic target for heart-related diseases. Furthermore, CCN5 has been found to have anti-inflammatory properties, making it a promising candidate for the treatment of inflammatory conditions. Its ability to regulate immune responses and modulate cytokine production highlights its potential as a target for managing inflammatory disorders. CCN5 has also been implicated in the regulation of metabolic processes and energy homeostasis. Research has shown that CCN5 can influence lipid metabolism and insulin sensitivity, suggesting its potential use in combating metabolic disorders such as obesity and diabetes.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eImmunohistochemistry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry O76076 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/O76076 - Gene search: WISP-2 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=WISP-2 - Ensembl search: WISP-2 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=WISP-2 - PubMed search: WISP-2 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=WISP-2+antibody - Reactome search: WISP-2 — Reactome — https:\/\/reactome.org\/content\/query?q=WISP-2 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53046412181869,"sku":"F55088-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53046471065965,"sku":"F55088-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_8a98ebf5-dbfc-40f2-96a4-1c395b06ddd0.jpg?v=1772000496","url":"https:\/\/www.ebiohippo.com\/products\/wisp-2-antibody-wnt1-inducible-signaling-pathway-protein-2-ccn5-bha17128151","provider":"BioHippo","version":"1.0","type":"link"}