{"product_id":"ym-01-bhb11900012","title":"YM-01","description":"\u003cp\u003eYM-01 is an allosteric inhibitor of Hsp70 that binds within its nucleotide-binding domain, adjacent to the ATP\/ADP pocket. It disrupts Hsc70-Bag1 interactions and enhances Hsp70 binding to misfolded proteins. In neuroscience, YM-01 has shown efficacy in reducing tau protein levels in cellular and animal models of tauopathy, including Alzheimer's disease. It restores long-term potentiation in brain slices from tau-overexpressing mice, indicating potential for cognitive recovery. YM-01’s dual activity in protein quality control and synaptic function makes it a valuable tool for studying and potentially treating tau-related neurodegenerative disorders.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"10 mg","offer_id":53040941072749,"sku":"SIH-121-10MG","price":189.0,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53040963715437,"sku":"SIH-121-25MG","price":378.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SIH-121_YM-01_Chemical_Structure.png?v=1771837627","url":"https:\/\/www.ebiohippo.com\/products\/ym-01-bhb11900012","provider":"BioHippo","version":"1.0","type":"link"}