{"product_id":"ym-90k-hydrochloride-bhb21300380","title":"YM 90K hydrochloride","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione hydrochloride.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 154164-30-4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C11H8ClN5O4.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 50 nM - 50 µM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e AMPA receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e YM 90K hydrochloride is a selective AMPA receptor antagonist; Ki of 84 nM1.\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eYM 90K is a selective and potent AMPA receptor antagonist. YM 90K inhibits the binding of [3H] AMPA with a Ki value of 84 nM1.YM 90K has been reported to have neuroprotective effects in focal and global cerebral ischaemia models. However, high or moderate doses of YM 90K induce behavioral changes, including sedation, muscular hypotonia and ataxia. In addition, the effects of YM 90K are short-lived. In this context, YM 90K may be useful for the treatment of acute epileptic conditions such as status epilepticus. Moreover, it might prevent pathological neuronal plasticity resulting from status epilepticus, since it shows an antiepileptogenic effect and protects hippocampal neurons during kainate-induced generalized seizures.YM 90K could be clinically useful, since a low dose exhibits significant, although weak effects against kindling without detectable behavioral adverse effects2.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249715208557,"sku":"Y-105-10MG-1","price":272.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311580340589,"sku":"Y-105-25MG-1","price":561.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311580373357,"sku":"Y-105-5MG-1","price":151.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311580406125,"sku":"Y-105-50MG-1","price":1003.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Y-105_gr-1.gif?v=1778544459","url":"https:\/\/www.ebiohippo.com\/products\/ym-90k-hydrochloride-bhb21300380","provider":"BioHippo","version":"1.0","type":"link"}