{"product_id":"zebrafish-abcc12-antibody-bha17136519","title":"Zebrafish Abcc12 Antibody","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Abcc12 Antibody is a anti-ABCC12 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Immunofluorescence (IF), IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ABCC12\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IF, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eZebrafish Abcc12 is a member of the ATP-binding cassette (ABC) transporter family, subfamily C. These transporters utilize ATP hydrolysis to move a variety of substrates across cellular membranes, including organic anions, lipids, and xenobiotics. Abcc12 is predicted to have multiple transmembrane domains and two nucleotide-binding domains characteristic of ABC transporters. In zebrafish, Abcc12 is thought to contribute to tissue-specific transport processes, potentially influencing developmental and physiological pathways.\u003cp\u003eSequence analysis indicates that zebrafish Abcc12 has a clear ortholog in humans, known as ABCC12 (also called MRP9), which is expressed in select tissues and has been studied in the context of membrane transport functions. The conservation between zebrafish and human orthologs supports the use of zebrafish Abcc12 in comparative studies aimed at understanding ABC transporter biology and substrate specificity.\u003c\/p\u003e\n\u003cp\u003eThe \u003cb\u003eAbcc12 antibody\u003c\/b\u003e is a valuable reagent for detecting zebrafish Abcc12 in applications such as western blot, immunohistochemistry, and immunofluorescence. Researchers use the Abcc12 antibody from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ABCC12 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ABCC12 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ABCC12 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ABCC12 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ABCC12+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml in PBS with 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3. \/ 200 ul","offer_id":53047332045165,"sku":"RZ1325","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9270b861-aa2e-44bc-8eae-f2376ec790bb.jpg?v=1772019477","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-abcc12-antibody-bha17136519","provider":"BioHippo","version":"1.0","type":"link"}