{"product_id":"zebrafish-androgen-receptor-antibody-ar-bha17136397","title":"Zebrafish Androgen receptor Antibody \/ AR","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Androgen receptor Antibody \/ AR is a anti-AR Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e AR\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eAndrogen receptor (AR) is a nuclear hormone receptor that functions as a ligand-activated transcription factor, mediating the biological effects of androgens such as testosterone and 11-ketotestosterone. In zebrafish (Danio rerio), AR plays a critical role in sex differentiation, reproductive organ development, and the regulation of secondary sexual characteristics.\u003cp\u003eUpon binding to its ligands, the zebrafish AR translocates to the nucleus, where it regulates the transcription of target genes involved in gonadal development, spermatogenesis, muscle growth, and behavioral traits associated with reproduction. Zebrafish express a single ar gene that is highly conserved with its mammalian counterparts and is expressed in tissues such as the gonads, brain, liver, and skin.\u003c\/p\u003e\n\u003cp\u003eZebrafish AR is widely used as a model for investigating androgen signaling pathways, endocrine disruption, and the mechanisms of sex hormone regulation in vertebrates. It is also of particular interest in toxicological studies, where it serves as a biomarker for assessing the effects of androgenic or anti-androgenic compounds in aquatic environments.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=AR - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=AR - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=AR - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/AR - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=AR+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047329227117,"sku":"RZ1202","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_56aae227-413b-4a8e-9475-b65b4b1a227c.jpg?v=1772019455","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-androgen-receptor-antibody-ar-bha17136397","provider":"BioHippo","version":"1.0","type":"link"}