{"product_id":"zebrafish-ascl1a-antibody-achaete-scute-homolog-1-bha17136398","title":"Zebrafish Ascl1a Antibody \/ Achaete-scute homolog 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Ascl1a Antibody \/ Achaete-scute homolog 1 is a anti-ASCL1A Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ASCL1A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eAchaete-scute family bHLH transcription factor 1a (Ascl1a) is a basic helix-loop-helix (bHLH) transcription factor that plays a crucial role in neurogenesis and cell fate determination. In zebrafish (Danio rerio), Ascl1a is a key regulator of neural progenitor proliferation and differentiation, particularly within the central nervous system, retina, and intestinal epithelium.\u003cp\u003eAscl1a acts downstream of proneural signaling pathways and promotes the commitment of progenitor cells to a neuronal lineage. It is expressed in neural precursor cells during embryonic development and is reactivated in regenerative contexts. In the zebrafish retina and brain, Ascl1a is essential for the regeneration of neurons following injury, making it a prominent factor in regenerative neurobiology.\u003c\/p\u003e\n\u003cp\u003eZebrafish Ascl1a is widely used as a model for studying the molecular mechanisms of neuronal differentiation, stem cell biology, and tissue regeneration. Its expression is tightly regulated by signaling pathways such as Notch, and its function is conserved across vertebrates, including in mammalian neurogenesis.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ASCL1A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ASCL1A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ASCL1A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ASCL1A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ASCL1A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328211309,"sku":"RZ1203","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ebc9f2bf-35ec-41f0-90c7-caf0f18ec6b0.jpg?v=1772019455","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-ascl1a-antibody-achaete-scute-homolog-1-bha17136398","provider":"BioHippo","version":"1.0","type":"link"}