{"product_id":"zebrafish-axin2-antibody-axis-inhibition-protein-2-bha17136400","title":"Zebrafish Axin2 Antibody \/ Axis inhibition protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Axin2 Antibody \/ Axis inhibition protein 2 is a anti-AXIN2 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e AXIN2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eAxin2 is a key scaffolding protein involved in the regulation of the Wnt\/Beta-catenin signaling pathway, a critical pathway for cell fate determination, embryonic patterning, and tissue homeostasis. In zebrafish (Danio rerio), Axin2 serves as both a negative regulator and a transcriptional target of Wnt signaling, establishing it as a vital component in feedback control of the pathway.\u003cp\u003eZebrafish axin2 is dynamically expressed during embryogenesis, particularly in regions undergoing active morphogenesis such as the neural tube, somites, and developing fins. By promoting the degradation of Beta-catenin, Axin2 attenuates Wnt signaling activity and ensures the precise spatial and temporal regulation of target gene expression. Its expression is commonly used as a molecular readout of Wnt\/Beta-catenin pathway activity in vivo.\u003c\/p\u003e\n\u003cp\u003eBecause of its highly conserved role in Wnt signaling, zebrafish Axin2 is widely utilized in studies of developmental biology, stem cell regulation, tissue regeneration, and cancer research. It also serves as an important biomarker for monitoring Wnt pathway modulation in both genetic and pharmacological studies.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=AXIN2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=AXIN2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=AXIN2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/AXIN2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=AXIN2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328407917,"sku":"RZ1205","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_bf5f7b87-9ac9-42e7-847d-91cccf3232df.jpg?v=1772019456","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-axin2-antibody-axis-inhibition-protein-2-bha17136400","provider":"BioHippo","version":"1.0","type":"link"}