{"product_id":"zebrafish-csf1r-antibody-m-csfr-bha17136432","title":"Zebrafish Csf1r Antibody \/ M-csfr","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Csf1r Antibody \/ M-csfr is a anti-CSF1R Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish. Reported localization: Cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CSF1R\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCsf1r, or colony stimulating factor one receptor, is a transmembrane receptor tyrosine kinase that plays an essential role in the development, differentiation, and function of cells in the mononuclear phagocyte system, including macrophages and microglia. In zebrafish, Csf1r is a key regulator of innate immune cell development and is critical for the maintenance of tissue resident macrophages during embryogenesis and adulthood.\u003cp\u003eCsf1r is activated by binding to its primary ligand, colony stimulating factor one, which triggers intracellular signaling pathways involved in cell survival, proliferation, and differentiation. In zebrafish, Csf1r is expressed in the yolk sac and hematopoietic tissues early in development and marks cells that give rise to macrophages, including microglia in the brain and Kupffer cells in the liver.\u003c\/p\u003e\n\u003cp\u003eDisruption of Csf1r function in zebrafish leads to reduced numbers or absence of tissue macrophages, providing a valuable model for studying the roles of these cells in development, immunity, and disease. Zebrafish Csf1r is widely used in research related to innate immunity, inflammation, neuroimmunology, and hematopoiesis.\u003c\/p\u003e\n\u003cp\u003eDue to its conservation across vertebrate species, zebrafish Csf1r is also a powerful tool for investigating genetic and pharmacological regulation of macrophage biology and for modeling diseases such as neurodegeneration and immune deficiencies.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CSF1R - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CSF1R - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CSF1R - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CSF1R - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CSF1R+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047329456493,"sku":"RZ1237","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_0621c334-939d-4c1e-8a9d-f22719d395db.jpg?v=1772019462","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-csf1r-antibody-m-csfr-bha17136432","provider":"BioHippo","version":"1.0","type":"link"}