{"product_id":"zebrafish-cxcl8a-antibody-il-8-bha17136407","title":"Zebrafish Cxcl8a Antibody \/ Il-8","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Cxcl8a Antibody \/ Il-8 is a anti-CXCL8A Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CXCL8A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCxcl8a, also known as Il-8 like a, is a chemokine that plays a key role in mediating the immune response, particularly by promoting the recruitment and activation of neutrophils. In zebrafish, Cxcl8a is a functional homolog of mammalian interleukin eight and is critical for the early innate immune defense against infection and tissue injury.\u003cp\u003eCxcl8a is produced by various cell types in response to inflammatory stimuli and acts through Cxcr receptors to direct the migration of neutrophils to sites of inflammation. In zebrafish embryos and larvae, Cxcl8a expression is rapidly upregulated following bacterial challenge, physical injury, or exposure to immune-modulating compounds.\u003c\/p\u003e\n\u003cp\u003eDue to the transparency and genetic tractability of zebrafish, Cxcl8a is widely used as a model to study inflammation, immune cell dynamics, and host pathogen interactions in vivo. It serves as a valuable biomarker for inflammation and is an important tool for investigating the effects of immunomodulatory drugs and environmental stressors.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CXCL8A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CXCL8A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CXCL8A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CXCL8A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CXCL8A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328768365,"sku":"RZ1212","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a610fd0d-363f-4873-a7cb-7e64b43bf919.jpg?v=1772019458","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-cxcl8a-antibody-il-8-bha17136407","provider":"BioHippo","version":"1.0","type":"link"}