{"product_id":"zebrafish-cyp11a1-1-antibody-cyp11a1-bha17136408","title":"Zebrafish Cyp11a1.1 Antibody \/ Cyp11a1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Cyp11a1.1 Antibody \/ Cyp11a1 is a anti-CYP11A1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CYP11A1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCyp11a1.1, or cytochrome P four five zero family eleven subfamily A polypeptide one point one, is an essential enzyme involved in the first and rate-limiting step of steroid hormone biosynthesis. In zebrafish, Cyp11a1.1 catalyzes the conversion of cholesterol to pregnenolone, a precursor for all classes of steroid hormones including glucocorticoids, mineralocorticoids, and sex steroids.\u003cp\u003eCyp11a1.1 is primarily expressed in steroidogenic tissues such as the interrenal gland, which is the functional equivalent of the adrenal gland in mammals, as well as in the gonads and brain. Its expression begins early in development and is tightly regulated by hormonal signals and developmental cues. Proper function of Cyp11a1.1 is essential for regulating processes such as stress response, growth, metabolism, and reproductive development.\u003c\/p\u003e\n\u003cp\u003eZebrafish Cyp11a1.1 is highly conserved and widely used in studies of endocrine system development, steroid biosynthesis, and hormone-related disorders. It is also a valuable model for understanding the molecular effects of endocrine-disrupting chemicals and for screening compounds that target steroidogenic pathways.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CYP11A1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CYP11A1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CYP11A1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CYP11A1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CYP11A1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328833901,"sku":"RZ1213","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b3114215-9b43-4d6c-8865-df2d18b78b63.jpg?v=1772019456","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-cyp11a1-1-antibody-cyp11a1-bha17136408","provider":"BioHippo","version":"1.0","type":"link"}