{"product_id":"zebrafish-cyp17a1-antibody-bha17136409","title":"Zebrafish Cyp17a1 Antibody","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Cyp17a1 Antibody is a anti-CYP17A1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish. Reported localization: Membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CYP17A1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCyp17a1, or cytochrome P four five zero family seventeen subfamily A polypeptide one, is a critical enzyme involved in the biosynthesis of steroid hormones. In zebrafish, Cyp17a1 performs both seventeen alpha hydroxylase and seventeen twenty lyase activities, enabling the production of key intermediates for the synthesis of glucocorticoids and sex steroids.\u003cp\u003eCyp17a1 is predominantly expressed in steroidogenic tissues such as the interrenal gland, gonads, and brain. During development, it is required for the proper formation of the endocrine system and plays a vital role in processes such as stress regulation, sexual differentiation, and reproduction. By controlling the production of hormones like cortisol, testosterone, and estradiol, Cyp17a1 supports a wide range of physiological functions including metabolism, immune regulation, and fertility.\u003c\/p\u003e\n\u003cp\u003eBecause of its conserved enzymatic role and tissue-specific expression, zebrafish Cyp17a1 is frequently used as a model to study endocrine system development, steroid hormone biosynthesis, and the impact of environmental or pharmaceutical compounds on hormone production. It is also valuable for research into adrenal and gonadal disorders.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CYP17A1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CYP17A1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CYP17A1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CYP17A1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CYP17A1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328440685,"sku":"RZ1214","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a2a65fcf-575c-48b2-931d-8f171c1598e9.jpg?v=1772019456","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-cyp17a1-antibody-bha17136409","provider":"BioHippo","version":"1.0","type":"link"}