{"product_id":"zebrafish-cyp26a1-antibody-cytochrome-p450-26a1-bha17136411","title":"Zebrafish Cyp26a1 Antibody \/ Cytochrome P450 26A1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Cyp26a1 Antibody \/ Cytochrome P450 26A1 is a anti-CYP26A1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CYP26A1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eCyp26a1, or cytochrome P four five zero family twenty six subfamily A polypeptide one, is an enzyme that plays a central role in regulating retinoic acid levels during vertebrate development. In zebrafish, Cyp26a1 is responsible for the metabolic breakdown of retinoic acid, ensuring the proper spatial and temporal control of retinoic acid signaling.\u003cp\u003eRetinoic acid is a derivative of vitamin A that functions as a key signaling molecule in embryogenesis, influencing processes such as axis formation, organ development, and cell differentiation. Cyp26a1 expression is tightly controlled and occurs in specific patterns that help shape retinoic acid gradients across developing tissues. In zebrafish embryos, Cyp26a1 is particularly important for the formation of the head, hindbrain, and somites.\u003c\/p\u003e\n\u003cp\u003eLoss of Cyp26a1 function disrupts retinoic acid homeostasis, leading to developmental abnormalities. Because of this, zebrafish Cyp26a1 is widely used as a model for studying retinoid metabolism, embryonic patterning, and the effects of vitamin A derivatives. It is also valuable in toxicological research for identifying compounds that interfere with retinoic acid signaling pathways.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CYP26A1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CYP26A1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CYP26A1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CYP26A1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CYP26A1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047327752557,"sku":"RZ1216","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_cf292930-392c-4157-873b-9baee2bceeb6.jpg?v=1772019457","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-cyp26a1-antibody-cytochrome-p450-26a1-bha17136411","provider":"BioHippo","version":"1.0","type":"link"}