{"product_id":"zebrafish-dnm1-antibody-dnm1a-dnm1b-dynamin-bha17136414","title":"Zebrafish Dnm1 Antibody \/ Dnm1a \/ Dnm1b \/ Dynamin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Dnm1 Antibody \/ Dnm1a \/ Dnm1b \/ Dynamin is a anti-DNM1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Immunofluorescence (IF), IHC-P with listed reactivity in Zebrafish. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e DNM1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IF, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eDnm1, or dynamin one, is a neuron-specific member of the dynamin family of large GTPase enzymes that are involved in membrane remodeling processes such as endocytosis and vesicle trafficking. In zebrafish, Dnm1 plays a critical role in the nervous system by facilitating the recycling of synaptic vesicles and maintaining efficient neurotransmission.\u003cp\u003eZebrafish express multiple dnm1 transcript variants that give rise to isoform a and isoform b, which may differ in their tissue distribution, regulatory elements, or functional properties. Both isoforms contribute to the dynamic regulation of synaptic membranes but may be expressed at different developmental stages or in distinct neuronal populations.\u003c\/p\u003e\n\u003cp\u003eDnm1 isoform a is typically expressed during early neural development and is enriched in regions of the brain with high synaptic activity. It supports the rapid and repeated cycles of vesicle fission that are essential for sustained neurotransmitter release.\u003c\/p\u003e\n\u003cp\u003eDnm1 isoform b may have overlapping or complementary roles to isoform a, potentially contributing to synaptic maintenance or plasticity in mature neurons. It may also be involved in neural differentiation and axonal growth during zebrafish development.\u003c\/p\u003e\n\u003cp\u003eBecause of its essential function in synaptic physiology, zebrafish Dnm1 is a widely used model for studying neural development, synaptic transmission, and neurological disorders associated with defects in vesicle recycling. It is particularly valuable in research on seizure susceptibility and developmental brain disorders, where Dnm1 mutations are known to have pathogenic effects in other vertebrates.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=DNM1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=DNM1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=DNM1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/DNM1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=DNM1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328145773,"sku":"RZ1219","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_4d1faa36-0473-4c35-9283-242486bcfbd0.jpg?v=1772019459","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-dnm1-antibody-dnm1a-dnm1b-dynamin-bha17136414","provider":"BioHippo","version":"1.0","type":"link"}