{"product_id":"zebrafish-e-cadherin-antibody-cdh1-cadherin-1-bha17136415","title":"Zebrafish E-cadherin Antibody \/ Cdh1 \/ Cadherin 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish E-cadherin Antibody \/ Cdh1 \/ Cadherin 1 is a anti-CDH1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Zebrafish. Reported localization: Cell membrane, cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e CDH1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eE cadherin, also known as epithelial cadherin, cadherin 1 and Cdh1, is a calcium dependent cell adhesion protein that plays a key role in maintaining epithelial tissue structure and integrity. In zebrafish, E cadherin is essential for early embryonic development, particularly during processes such as epiboly, gastrulation, and organ formation.\u003cp\u003eE cadherin is a transmembrane glycoprotein that mediates homophilic cell to cell adhesion by forming adherens junctions between neighboring epithelial cells. It is a critical component of the cadherin catenin complex, which connects the actin cytoskeleton to the plasma membrane, thereby regulating tissue architecture and cell polarity.\u003c\/p\u003e\n\u003cp\u003eIn zebrafish embryos, E cadherin is expressed from the earliest stages of development and is especially important for coordinating cell movements and maintaining cohesion during morphogenesis. Loss or disruption of E cadherin function leads to severe defects in cell adhesion, tissue separation, and embryonic patterning.\u003c\/p\u003e\n\u003cp\u003eBecause of its conserved role in epithelial biology, zebrafish E cadherin is widely used in research focused on developmental biology, cancer metastasis, tissue regeneration, and epithelial to mesenchymal transition. It also serves as a valuable marker for epithelial cell identity and cell junction integrity in various model systems.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=CDH1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=CDH1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=CDH1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/CDH1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=CDH1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328702829,"sku":"RZ1220","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_64aba932-ffc2-4af8-a7a5-ad709d0e0a91.jpg?v=1772019461","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-e-cadherin-antibody-cdh1-cadherin-1-bha17136415","provider":"BioHippo","version":"1.0","type":"link"}