{"product_id":"zebrafish-estrogen-receptor-2b-antibody-esr2b-bha17136416","title":"Zebrafish Estrogen receptor 2b Antibody \/ Esr2b","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Estrogen receptor 2b Antibody \/ Esr2b is a anti-2B Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e 2B\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eEsr2b, or estrogen receptor 2b, is one of the two estrogen receptor beta isoforms found in zebrafish and is part of the nuclear receptor family of transcription factors. Esr2b plays a key role in mediating the biological effects of estrogens by regulating the expression of target genes involved in development, reproduction, and homeostasis.\u003cp\u003eIn zebrafish, Esr2b is expressed in a variety of tissues including the brain, liver, gonads, and developing embryos. Upon binding to estrogens such as estradiol, Esr2b translocates to the nucleus where it binds to specific DNA sequences known as estrogen response elements to modulate gene transcription. Esr2b has been shown to influence processes such as sexual differentiation, oocyte maturation, and endocrine signaling.\u003c\/p\u003e\n\u003cp\u003eEsr2b is functionally distinct from the closely related Esr2a and Esr1 receptors, and its expression pattern suggests it may have specialized roles in estrogen signaling pathways. Zebrafish provide a powerful model to study Esr2b function in vivo, including the effects of environmental estrogens and endocrine disrupting compounds on gene regulation and reproductive health.\u003c\/p\u003e\n\u003cp\u003eDue to its importance in estrogen mediated gene regulation and its responsiveness to hormonal and environmental cues, zebrafish Esr2b is widely used in research focused on reproductive biology, developmental endocrinology, toxicology, and hormone responsive gene networks.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=2B - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=2B - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=2B - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/2B - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=2B+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328309613,"sku":"RZ1221","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_dafe0c66-b755-447e-bf48-f572d3aebb4e.jpg?v=1772019458","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-estrogen-receptor-2b-antibody-esr2b-bha17136416","provider":"BioHippo","version":"1.0","type":"link"}