{"product_id":"zebrafish-etv4-antibody-ets-translocation-variant-4-pea3-bha17136373","title":"Zebrafish Etv4 Antibody \/ ETS translocation variant 4 \/ Pea3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Etv4 Antibody \/ ETS translocation variant 4 \/ Pea3 is a anti-ETV4 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ETV4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eEts variant 4 (Etv4), also known as Pea3, is a member of the ETS family of transcription factors characterized by a conserved ETS DNA-binding domain that recognizes purine-rich sequences in target gene promoters. In zebrafish (Danio rerio), etv4 plays an essential role in embryonic development, particularly in processes regulated by fibroblast growth factor (FGF) signaling.\u003cp\u003eEtv4 functions as a key downstream effector of FGF signaling pathways, mediating transcriptional responses critical for tissue patterning and organogenesis. During zebrafish embryogenesis, etv4 is expressed in a variety of dynamic domains including the posterior mesoderm, developing somites, neural crest, and the pronephros. It acts in concert with other Pea3 subfamily members such as Etv5 to regulate genes involved in cell migration, proliferation, and differentiation.\u003c\/p\u003e\n\u003cp\u003eZebrafish etv4 has been extensively studied in the context of limb and fin development, neuromast formation, and branchial arch morphogenesis, making it a useful molecular marker for FGF activity and mesenchymal-epithelial interactions. Disruption of etv4 expression or function impairs normal developmental processes, underscoring its regulatory importance.\u003c\/p\u003e\n\u003cp\u003eDue to its conserved function and regulated expression, zebrafish Etv4 serves as a valuable model for studying ETS transcription factors in vertebrate development and disease pathways, including cancer metastasis and skeletal disorders.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ETV4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ETV4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ETV4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ETV4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ETV4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047327064429,"sku":"RZ1178","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a1c3cb0c-4a99-473c-8292-9b604ddfe1ed.jpg?v=1772019452","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-etv4-antibody-ets-translocation-variant-4-pea3-bha17136373","provider":"BioHippo","version":"1.0","type":"link"}