{"product_id":"zebrafish-fshb-antibody-follicle-stimulating-hormone-beta-bha17136377","title":"Zebrafish Fshb Antibody \/ Follicle stimulating hormone beta","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Fshb Antibody \/ Follicle stimulating hormone beta is a anti-Zebrafish Fshb Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Zebrafish Fshb\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eFollicle-stimulating hormone (FSH) is a key glycoprotein hormone involved in the regulation of reproductive processes across vertebrate species. It is composed of a common alpha subunit and a hormone-specific beta subunit, with the beta subunit (Fshb) conferring biological specificity. In zebrafish (Danio rerio), the fshb gene encodes the beta subunit of FSH and is expressed in gonadotrope cells of the anterior pituitary.\u003cp\u003eZebrafish Fshb plays a crucial role in the development and maturation of gametes, particularly in promoting folliculogenesis in females and spermatogonial proliferation in males. Its expression and secretion are primarily regulated by gonadotropin-releasing hormone (GnRH) and modulated by feedback from sex steroids and other endocrine factors within the hypothalamic-pituitary-gonadal (HPG) axis.\u003c\/p\u003e\n\u003cp\u003eDuring zebrafish development, fshb expression becomes evident post-embryonically and increases with sexual maturation. Functional studies have shown that Fshb is essential for early-stage follicle development and the onset of puberty, while also contributing to basal steroidogenesis in the gonads.\u003c\/p\u003e\n\u003cp\u003eGiven the genetic accessibility and transparency of zebrafish, the fshb gene and its protein product are commonly used in reproductive biology, toxicology, and endocrine disruption studies. Zebrafish Fshb shares structural and functional homology with its mammalian counterparts, making it a valuable model for exploring conserved mechanisms of vertebrate reproduction.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=Zebrafish+Fshb - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Zebrafish+Fshb - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Zebrafish+Fshb - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/Zebrafish+Fshb - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zebrafish+Fshb+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047326998893,"sku":"RZ1182","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_22a05773-d405-4a1d-a741-e4ec76a29d58.jpg?v=1772019453","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-fshb-antibody-follicle-stimulating-hormone-beta-bha17136377","provider":"BioHippo","version":"1.0","type":"link"}