{"product_id":"zebrafish-gata3-antibody-gata-binding-factor-3-bha17136387","title":"Zebrafish Gata3 Antibody \/ GATA binding factor 3","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Gata3 Antibody \/ GATA binding factor 3 is a anti-GATA3 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GATA3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGATA-binding protein 3 (Gata3) is a zinc finger transcription factor of the GATA family that regulates gene expression during embryonic development and cellular differentiation. In zebrafish (Danio rerio), Gata3 plays essential roles in the development of the nervous system, kidney (pronephros), inner ear, and components of the immune system.\u003cp\u003eGata3 is expressed early in development and is particularly active in neural crest derivatives, including the sympathetic nervous system, sensory neurons, and otic vesicle. It is also involved in nephrogenesis, where it regulates the patterning and differentiation of the pronephric duct and tubules. Functional studies have shown that loss of gata3 disrupts normal development of the auditory system, leading to defects in otic vesicle morphology and neurosensory patterning.\u003c\/p\u003e\n\u003cp\u003eDue to its evolutionary conservation and regulatory importance, zebrafish Gata3 serves as a valuable model for studying neuronal specification, ear development, and renal morphogenesis, as well as immune system development—particularly T-cell differentiation in vertebrates.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GATA3 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GATA3 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GATA3 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GATA3 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GATA3+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328964973,"sku":"RZ1192","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f14a4f58-154d-4143-a891-1755ddb023a6.jpg?v=1772019453","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-gata3-antibody-gata-binding-factor-3-bha17136387","provider":"BioHippo","version":"1.0","type":"link"}