{"product_id":"zebrafish-gata6-antibody-gata-binding-factor-6-bha17136386","title":"Zebrafish Gata6 Antibody \/ GATA-binding factor 6","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Gata6 Antibody \/ GATA-binding factor 6 is a anti-GATA6 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GATA6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGATA-binding protein 6 (Gata6) is a zinc finger transcription factor belonging to the GATA family, which regulates gene expression during embryonic development and cell lineage specification. In zebrafish (Danio rerio), Gata6 plays a key role in the development of the endoderm, heart, and gut, as well as in organ morphogenesis and tissue differentiation.\u003cp\u003eDuring early zebrafish embryogenesis, Gata6 is expressed in the endodermal and mesodermal layers, where it works in concert with Gata4 and Gata5 to specify endodermal fate and initiate the morphogenesis of organs such as the liver, pancreas, and intestine. It also contributes to cardiac progenitor specification and the formation of the heart tube, making it essential for proper cardiovascular development.\u003c\/p\u003e\n\u003cp\u003eDue to its high conservation and central role in organogenesis, zebrafish Gata6 is widely used as a model to study developmental gene regulation, cardiogenesis, and congenital diseases affecting the heart and gastrointestinal tract. It is also a valuable marker for analyzing endodermal derivatives and early tissue patterning in vertebrate embryos.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GATA6 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GATA6 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GATA6 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GATA6 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GATA6+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047327490413,"sku":"RZ1191","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_34718805-3d8f-4804-a6b8-ce2942d917f0.jpg?v=1772019452","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-gata6-antibody-gata-binding-factor-6-bha17136386","provider":"BioHippo","version":"1.0","type":"link"}