{"product_id":"zebrafish-gfap-antibody-glial-fibrillary-acidic-protein-bha17136420","title":"Zebrafish Gfap Antibody \/ Glial fibrillary acidic protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Gfap Antibody \/ Glial fibrillary acidic protein is a anti-Zebrafish Gfap Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Zebrafish Gfap\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGfap, or glial fibrillary acidic protein, is an intermediate filament protein that serves as a key structural and functional component of astroglial cells in the central nervous system. In zebrafish, Gfap is widely used as a marker for radial glial cells, which function as neural progenitors during early brain development and also provide structural support to the developing nervous system.\u003cp\u003eGfap is strongly expressed in the neural tube, spinal cord, and brain ventricles of developing zebrafish embryos. These radial glial cells give rise to neurons and glia, making Gfap expression an important indicator of neurogenesis. In the mature zebrafish brain, Gfap remains expressed in astroglia and is associated with neural maintenance, repair, and regeneration.\u003c\/p\u003e\n\u003cp\u003eBecause zebrafish have a high capacity for neural regeneration, Gfap is also commonly used to study injury responses and repair mechanisms in the brain and spinal cord. The conservation of Gfap structure and function across vertebrates makes zebrafish a valuable model for understanding the roles of glial cells in development, neurodegeneration, and central nervous system diseases.\u003c\/p\u003e\n\u003cp\u003eZebrafish Gfap is widely applied in developmental neuroscience, regenerative medicine, and glial biology research. It is also a standard marker in transgenic models used to trace glial lineages and study brain architecture.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=Zebrafish+Gfap - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Zebrafish+Gfap - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Zebrafish+Gfap - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/Zebrafish+Gfap - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zebrafish+Gfap+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328276845,"sku":"RZ1225","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_2a95a27a-32d2-4efc-985b-8e155ae0906b.jpg?v=1772019459","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-gfap-antibody-glial-fibrillary-acidic-protein-bha17136420","provider":"BioHippo","version":"1.0","type":"link"}