{"product_id":"zebrafish-glucocorticoid-receptor-antibody-gr-nr3c1-bha17136421","title":"Zebrafish Glucocorticoid receptor Antibody \/ Gr \/ Nr3c1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Glucocorticoid receptor Antibody \/ Gr \/ Nr3c1 is a anti-NR3C1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NR3C1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGlucocorticoid receptor (Gr), also known as nuclear receptor subfamily three group C member one (Nr3c1), is a ligand activated transcription factor that mediates the effects of glucocorticoid hormones such as cortisol. In zebrafish, the glucocorticoid receptor plays a central role in regulating stress responses, metabolism, immune function, and early embryonic development.\u003cp\u003eThe zebrafish glucocorticoid receptor is expressed in a wide range of tissues including the brain, liver, muscle, and developing endocrine organs. Upon binding to glucocorticoids, the receptor translocates to the nucleus where it binds specific DNA sequences and modulates the transcription of target genes involved in maintaining homeostasis under stress conditions. It also influences cell differentiation, energy balance, and the inflammatory response.\u003c\/p\u003e\n\u003cp\u003eIn zebrafish embryos, activation or disruption of glucocorticoid signaling affects key developmental processes such as axis formation, organ maturation, and behavioral programming. Because zebrafish produce cortisol as their primary glucocorticoid, they serve as a powerful model for investigating hormone signaling and endocrine regulation in vertebrates.\u003c\/p\u003e\n\u003cp\u003eThe glucocorticoid receptor in zebrafish is widely used in research on stress physiology, neuroendocrine development, immune modulation, and environmental toxicology. It is also a valuable target in studies examining the effects of synthetic glucocorticoids and endocrine disrupting compounds.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=NR3C1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=NR3C1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=NR3C1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/NR3C1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=NR3C1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047329194349,"sku":"RZ1226","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_23d15218-b5d1-4f07-861c-91fc990e3298.jpg?v=1772019459","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-glucocorticoid-receptor-antibody-gr-nr3c1-bha17136421","provider":"BioHippo","version":"1.0","type":"link"}