{"product_id":"zebrafish-gnrh2-antibody-gonadotropin-releasing-hormone-2-progonadoliberin-bha17136380","title":"Zebrafish Gnrh2 Antibody \/ Gonadotropin-releasing hormone 2 \/ Progonadoliberin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Gnrh2 Antibody \/ Gonadotropin-releasing hormone 2 \/ Progonadoliberin is a anti-GNRH2 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GNRH2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGonadotropin-releasing hormone 2 (Gnrh2) is a neuropeptide encoded by the gnrh2 gene in zebrafish (Danio rerio) and belongs to the conserved family of GnRH peptides that play essential roles in the regulation of reproductive physiology. Gnrh2 is primarily expressed in the midbrain tegmentum and is involved in modulating reproductive behavior, neuroendocrine signaling, and possibly feeding and locomotor activity.\u003cp\u003eUnlike Gnrh1, which is the main hypophysiotropic form regulating pituitary gonadotropin release, Gnrh2 is considered a non-hypophysiotropic GnRH variant and is thought to function in neuromodulation and reproductive behavior across vertebrates. In zebrafish, Gnrh2-expressing neurons have been implicated in the integration of sensory and hormonal signals, contributing to the fine-tuning of reproductive timing and behavior in response to environmental cues.\u003c\/p\u003e\n\u003cp\u003eDue to its evolutionary conservation and tissue-specific expression, zebrafish Gnrh2 is a valuable model for studying neuroendocrine regulation, sexual behavior, and the functional diversification of GnRH isoforms.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GNRH2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GNRH2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GNRH2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GNRH2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GNRH2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047327261037,"sku":"RZ1185","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_6cf8a2d3-b78c-4aa4-957d-c08666fba739.jpg?v=1772019453","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-gnrh2-antibody-gonadotropin-releasing-hormone-2-progonadoliberin-bha17136380","provider":"BioHippo","version":"1.0","type":"link"}