{"product_id":"zebrafish-hand2-antibody-heart-and-neural-crest-derivatives-expressed-2-bha17136422","title":"Zebrafish Hand2 Antibody \/ Heart and neural crest derivatives expressed 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Hand2 Antibody \/ Heart and neural crest derivatives expressed 2 is a anti-HAND2 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e HAND2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eHand2, or heart and neural crest derivatives expressed two, is a basic helix loop helix transcription factor that plays a vital role in the development of the heart, limbs, and neural crest derived tissues. In zebrafish, Hand2 is essential for proper cardiac morphogenesis, vascular development, and craniofacial patterning.\u003cp\u003eDuring early zebrafish embryogenesis, Hand2 is expressed in the lateral plate mesoderm and contributes to the specification and differentiation of cardiac progenitor cells. It is particularly important for the formation of the heart tube and for the development of the atrial and ventricular chambers. Hand2 also regulates the migration and function of neural crest cells, which give rise to structures such as the jaw and pharyngeal arches.\u003c\/p\u003e\n\u003cp\u003eLoss of Hand2 function in zebrafish leads to severe defects in heart formation, including impaired looping and chamber development, as well as abnormalities in craniofacial structures. Because of its conserved role in vertebrate development, zebrafish Hand2 is widely used as a model for studying congenital heart defects, craniofacial malformations, and the genetic pathways that guide mesodermal and neural crest cell differentiation.\u003c\/p\u003e\n\u003cp\u003eZebrafish Hand2 is a valuable tool in developmental biology, regenerative medicine, and disease modeling, particularly in research focused on cardiac development and structural birth defects.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=HAND2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=HAND2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=HAND2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/HAND2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=HAND2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328801133,"sku":"RZ1227","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b8265b4d-07c6-4354-993e-7bee7463945a.jpg?v=1772019459","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-hand2-antibody-heart-and-neural-crest-derivatives-expressed-2-bha17136422","provider":"BioHippo","version":"1.0","type":"link"}