{"product_id":"zebrafish-her4-antibody-her4-1-her4-2-her4-3-her4-5-bha17136383","title":"Zebrafish Her4 Antibody \/ Her4.1 \/ Her4.2 \/ Her4.3 \/ Her4.5","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Her4 Antibody \/ Her4.1 \/ Her4.2 \/ Her4.3 \/ Her4.5 is a anti-HER4 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish. Reported localization: Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e HER4\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eHer4 (Hairy-related 4, Transcription factor HES-5) is a basic helix-loop-helix (bHLH) transcriptional repressor belonging to the hairy\/enhancer-of-split-related (Her\/Hes) family of genes. In zebrafish (Danio rerio), Her4 is a downstream effector of the Notch signaling pathway and plays a central role in the regulation of neurogenesis and cell fate determination during embryonic development.\u003cp\u003eHer4 is prominently expressed in the developing central nervous system, where it maintains neural progenitor populations by inhibiting premature neuronal differentiation. By repressing proneural gene expression, Her4 ensures the proper timing and patterning of neuron formation. It also contributes to lateral inhibition, a process critical for the spatial organization of neural tissues.\u003c\/p\u003e\n\u003cp\u003eBecause of its well-characterized role in Notch-mediated signaling and neurodevelopment, zebrafish Her4 is frequently used as a molecular marker for neural progenitor cells and as a model to study stem cell maintenance, differentiation, and the impact of disrupted Notch signaling in developmental disorders and disease.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=HER4 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=HER4 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=HER4 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/HER4 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=HER4+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047327392109,"sku":"RZ1188","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_811fc710-aa40-4341-9385-f1e646ab162a.jpg?v=1772019452","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-her4-antibody-her4-1-her4-2-her4-3-her4-5-bha17136383","provider":"BioHippo","version":"1.0","type":"link"}