{"product_id":"zebrafish-hhex-antibody-hex-hematopoietically-expressed-homeobox-protein-bha17136424","title":"Zebrafish Hhex Antibody \/ Hex \/ Hematopoietically expressed homeobox protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Hhex Antibody \/ Hex \/ Hematopoietically expressed homeobox protein is a anti-Zebrafish Hhex Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e Zebrafish Hhex\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eHhex, or hematopoietically expressed homeobox, is a transcription factor that plays a critical role in early embryonic development, especially in the formation of the forebrain, thyroid, liver, and pancreas. In zebrafish, Hhex is essential for the specification and differentiation of endodermal and anterior mesodermal tissues.\u003cp\u003eHhex is expressed early in the developing embryo, particularly in regions that give rise to the anterior foregut and associated organs. It regulates the expression of key developmental genes involved in organogenesis and is required for proper morphogenesis of the thyroid gland and liver. In the developing brain, Hhex also contributes to the patterning of forebrain structures.\u003c\/p\u003e\n\u003cp\u003eLoss of Hhex function in zebrafish leads to defects in anterior endoderm formation, impaired thyroid and liver development, and abnormalities in forebrain organization. Because of its conserved function in vertebrate development, zebrafish Hhex serves as a valuable model for understanding congenital organ defects, endodermal lineage specification, and early tissue patterning.\u003c\/p\u003e\n\u003cp\u003eZebrafish Hhex is widely used in developmental biology, stem cell research, and disease modeling, particularly in studies focused on endocrine and hepatic organ development.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=Zebrafish+Hhex - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=Zebrafish+Hhex - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=Zebrafish+Hhex - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/Zebrafish+Hhex - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zebrafish+Hhex+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328866669,"sku":"RZ1229","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_1451a379-5516-463b-a695-e1b29f1d297a.jpg?v=1772019461","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-hhex-antibody-hex-hematopoietically-expressed-homeobox-protein-bha17136424","provider":"BioHippo","version":"1.0","type":"link"}