{"product_id":"zebrafish-hmox1a-antibody-hmox1-heme-oxygenase-bha17136388","title":"Zebrafish Hmox1a Antibody \/ Hmox1 \/ Heme oxygenase","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Hmox1a Antibody \/ Hmox1 \/ Heme oxygenase is a anti-HMOX1A Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Zebrafish. Reported localization: Cytoplasm (ER).\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e HMOX1A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eHeme oxygenase 1a (Hmox1a) is one of the zebrafish homologs of the mammalian heme oxygenase 1 (HMOX1), an essential enzyme that catalyzes the degradation of heme into biliverdin, free iron, and carbon monoxide. In zebrafish (Danio rerio), Hmox1a plays a critical role in oxidative stress response, iron homeostasis, and anti-inflammatory signaling, and is a key marker of cellular stress.\u003cp\u003eHmox1a is inducible under a variety of stress conditions, including oxidative damage, hypoxia, heavy metal exposure, and inflammation. Its expression is regulated by transcription factors such as Nrf2 and Bach1. Zebrafish hmox1a is highly conserved and is expressed in multiple tissues including the liver, kidney, and vasculature, especially under stress or injury.\u003c\/p\u003e\n\u003cp\u003eZebrafish provide a powerful in vivo model for studying Hmox1a function in developmental biology, toxicology, inflammation, and iron metabolism. Because of its conservation with mammalian HMOX1, hmox1a is widely used in research on antioxidant defense, redox signaling, and as a readout for environmental and pharmaceutical stress responses.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=HMOX1A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=HMOX1A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=HMOX1A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/HMOX1A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=HMOX1A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328080237,"sku":"RZ1193","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_607c0ba7-f4c7-4e7d-bf9c-74e2342259c0.jpg?v=1772019454","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-hmox1a-antibody-hmox1-heme-oxygenase-bha17136388","provider":"BioHippo","version":"1.0","type":"link"}