{"product_id":"zebrafish-igf2a-antibody-igf2-insulin-like-growth-factor-2-bha17136394","title":"Zebrafish Igf2a Antibody \/ Igf2 \/ Insulin-like growth factor 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Igf2a Antibody \/ Igf2 \/ Insulin-like growth factor 2 is a anti-IGF2A Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IGF2A\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eInsulin-like growth factor 2a (Igf2a) is one of two zebrafish paralogs of the mammalian IGF2, a growth factor involved in regulating cell proliferation, differentiation, metabolism, and survival. In zebrafish (Danio rerio), Igf2a plays a key role in embryonic growth, organ development, and tissue regeneration, acting through the IGF signaling axis that is conserved across vertebrates.\u003cp\u003eIgf2a functions by binding to the insulin-like growth factor 1 receptor (IGF1R), activating downstream signaling pathways such as PI3K-Akt and MAPK\/ERK, which promote anabolic processes and inhibit apoptosis. In zebrafish, igf2a is expressed during early development and in growing tissues such as the heart, liver, and muscle, and has been shown to influence myogenesis, neurogenesis, and organ size regulation.\u003c\/p\u003e\n\u003cp\u003eDue to its importance in growth and regenerative pathways, zebrafish Igf2a is widely used as a model for studying developmental biology, metabolic regulation, and growth-related disorders. It is also of interest in research on wound healing, cardiac regeneration, and tumor biology.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IGF2A - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IGF2A - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IGF2A - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IGF2A - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IGF2A+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047327555949,"sku":"RZ1199","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_bfdada57-d56d-485f-b757-e8828d8f8880.jpg?v=1772019455","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-igf2a-antibody-igf2-insulin-like-growth-factor-2-bha17136394","provider":"BioHippo","version":"1.0","type":"link"}