{"product_id":"zebrafish-il-1-beta-antibody-il1b-interleukin-1-bha17136426","title":"Zebrafish Il-1 beta Antibody \/ Il1b \/ Interleukin 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Il-1 beta Antibody \/ Il1b \/ Interleukin 1 is a anti-IL-1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IL-1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eIl1b, or interleukin one beta, is a proinflammatory cytokine that plays a central role in the innate immune response. In zebrafish, Il1b functions similarly to its mammalian counterpart by promoting inflammation, activating immune cells, and mediating responses to infection and tissue injury.\u003cp\u003eIl1b is primarily produced by macrophages and other immune cells following recognition of pathogens or cellular damage. Once activated, Il1b initiates a cascade of signaling events that result in the expression of additional cytokines, chemokines, and adhesion molecules, thereby amplifying the inflammatory response. In zebrafish, Il1b is expressed early during immune challenge and is a key marker of immune system activation.\u003c\/p\u003e\n\u003cp\u003eIl1b is also involved in the regulation of hematopoiesis, fever, and wound healing. Its expression is tightly controlled at both the transcriptional and posttranslational levels to ensure a balanced immune response. Disruption or overactivation of Il1b can lead to excessive inflammation and tissue damage.\u003c\/p\u003e\n\u003cp\u003eDue to its evolutionary conservation and well defined function, zebrafish Il1b is widely used in studies of inflammation, infection, immune system development, and inflammatory disease models. It serves as a valuable tool for drug screening and for investigating the molecular pathways that regulate cytokine signaling in vertebrates.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IL-1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IL-1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IL-1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IL-1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IL-1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047329325421,"sku":"RZ1231","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f0b72c0a-24de-4a00-881d-2a04141f6281.jpg?v=1772019463","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-il-1-beta-antibody-il1b-interleukin-1-bha17136426","provider":"BioHippo","version":"1.0","type":"link"}