{"product_id":"zebrafish-insulin-like-growth-factor-1-antibody-igf1-bha17136425","title":"Zebrafish Insulin like growth factor 1 Antibody \/ Igf1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eZebrafish Insulin like growth factor 1 Antibody \/ Igf1 is a anti-IGF1 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as IHC-P with listed reactivity in Zebrafish.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IGF1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit Ig\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC-P\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eInsulin like growth factor 1, also known as IGF1, is a peptide growth factor that plays a key role in regulating cell growth, differentiation, and survival. In zebrafish, insulin like growth factor 1 is essential for normal embryonic development, tissue regeneration, and metabolic regulation.\u003cp\u003eIGF1 is produced mainly in the liver and acts both locally and systemically through endocrine and paracrine signaling. It mediates many of the growth promoting effects of growth hormone and functions by binding to its specific receptor on the cell surface, triggering downstream signaling pathways that influence cell cycle progression, protein synthesis, and apoptosis inhibition.\u003c\/p\u003e\n\u003cp\u003eIn zebrafish, insulin like growth factor 1 is involved in the development of multiple organs including the brain, heart, and skeletal muscle. It also supports fin regeneration and contributes to recovery from injury by promoting cell proliferation and tissue remodeling. IGF1 expression is sensitive to nutritional status and environmental factors, making it a key biomarker for growth and metabolic studies.\u003c\/p\u003e\n\u003cp\u003eDue to its strong conservation across vertebrates and its broad physiological importance, zebrafish insulin like growth factor 1 is widely used in research related to developmental biology, growth regulation, endocrine function, metabolic disease, and regenerative medicine.\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IGF1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IGF1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IGF1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IGF1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IGF1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"0.5mg\/ml if reconstituted with 0.2ml sterile DI water \/ 100 ug","offer_id":53047328997741,"sku":"RZ1230","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ab040cb9-0806-4b32-a137-c13842919e1e.jpg?v=1772019461","url":"https:\/\/www.ebiohippo.com\/products\/zebrafish-insulin-like-growth-factor-1-antibody-igf1-bha17136425","provider":"BioHippo","version":"1.0","type":"link"}